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<p>To determine genome-wide transcriptional coverage of well-characterized genes, gene candidates, and splice variants associated with invasive process on bladder carcinogenesis (BC), we investigated the whole-genome gene expression profile of high-grade Turkish BC patients. We collected high-grade bladder tumours (<i>n</i> = 12) and paired standard tissue samples (<i>n</i> = 12). To find differentially expressed genes related to bladder cancer’s metastatic pattern, we performed the human whole-genome expression profiling through the Illumina Human HT-12 Expression Beadchip system. Ingenuity Pathway Systems (IPA), i-Pathway Guide and Cytoscape software were used to determine statistically significant genes, networks, biological pathways between tumour and control groups. Cyclin A2 (CCNA2), CDC20, CDC45, MMP1, MMP3, MMP9, MMP10, STAT1, STAT2, TNFRSF1A, TNFSF10, and TUBB3 were significantly upregulated in bladder cancer cases. We showed that biological reactions, including the degradation of collagen and extracellular matrix and matrix metalloproteinases activation reactions, were found the most statistically significant pathways in BC. We also determined that inflammation and cytokine signalling could be related to the progression of bladder carcinogenesis. The genes differentially expressed could be molecular indicators for early prediction of bladder carcinogenesis.</p>

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Genome-wide transcriptional profiling identifies molecular markers associated with early carcinogenesis in high-grade bladder cancer

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月26日

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  • Rifat Burak Ergul,
  • Canan Kucukgergin,
  • Zeynep Birsu Cincin,
  • Bedia Cakmakoglu,
  • Selcuk Erdem,
  • Tzevat Tefik,
  • Mehmet Oner Sanli,
  • Ismet Nane,
  • Faruk Ozcan,
  • Sule Seckin

摘要

To determine genome-wide transcriptional coverage of well-characterized genes, gene candidates, and splice variants associated with invasive process on bladder carcinogenesis (BC), we investigated the whole-genome gene expression profile of high-grade Turkish BC patients. We collected high-grade bladder tumours (n = 12) and paired standard tissue samples (n = 12). To find differentially expressed genes related to bladder cancer’s metastatic pattern, we performed the human whole-genome expression profiling through the Illumina Human HT-12 Expression Beadchip system. Ingenuity Pathway Systems (IPA), i-Pathway Guide and Cytoscape software were used to determine statistically significant genes, networks, biological pathways between tumour and control groups. Cyclin A2 (CCNA2), CDC20, CDC45, MMP1, MMP3, MMP9, MMP10, STAT1, STAT2, TNFRSF1A, TNFSF10, and TUBB3 were significantly upregulated in bladder cancer cases. We showed that biological reactions, including the degradation of collagen and extracellular matrix and matrix metalloproteinases activation reactions, were found the most statistically significant pathways in BC. We also determined that inflammation and cytokine signalling could be related to the progression of bladder carcinogenesis. The genes differentially expressed could be molecular indicators for early prediction of bladder carcinogenesis.