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<p>Atherosclerotic cardiovascular disease (ASCVD) is a major cause of mortality worldwide. This study aims to investigate the relationship between the 10-year ASCVD risk score and mental disorders.This study analyzed data from 1154 participants aged 25 to 70 enrolled in the Shiraz Heart Study cohort between 2016 and 2019. The ten-year ASCVD risk score was estimated using the ASCVD risk score estimator recommended by the American College of Cardiology and American Heart Association guidelines. Mental health was evaluated using a 28-item general health questionnaire concurrently with the ASCVD risk calculation. A multiple logistic regression model was employed for multivariate analysis. The mean age of participants was 44.25 ± 8.88 years, and most were men (<i>n</i> = 621, 53.8%). A multiple logistic regression model demonstrated that having ASCVD is associated with increased odds of somatic symptoms (OR 1.138, 95% CI 1.069–1.212), anxiety and insomnia (OR 1.113, 95% CI 1.043–1.188), severe depression (OR 1.173, 95% CI 1.084–1.269), and total general health scores (OR 1.053, CI 1.027–1.079). Another multiple logistic regression model showed that among participants without ASCVD, 10-year ASCVD risk score ≥ 5% is associated with increased odds of somatic symptoms (OR 1.126 95%CI 1.035–1.224), anxiety and insomnia (OR 1.117, 95% CI 1.031–1.211), social dysfunction (OR 1.121, 95% CI 1.034–1.215), severe depression (OR 1.195, 95% CI 1.078–1.324), and total general health scores (OR 1.068, CI 1.035–1.102). ASCVD and a 10-year ASCVD risk score ≥ 5 are associated with the development of mental disorders.</p>

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The effects of atherosclerotic cardiovascular disease and ten-year atherosclerotic cardiovascular disease risk score on mental health status

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月23日

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  • Mohammad Javad Zibaeenezhad,
  • Javad Molazadeh,
  • Mehrab Sayadi,
  • Fatemeh Bamooee Fard,
  • Mahdi Rahmanian,
  • Aida Bazrgar,
  • Mehdi Bazrafshan,
  • Nader Parsa,
  • Iman Razeghian-Jahromi,
  • Seyyed Saeed Mohammadi,
  • Fatemeh Zibaeenejad,
  • Hamed Bazrafshan drissi,
  • Sheikh Mohammed Shariful Islam,
  • Roohollah Alizadehsani

摘要

Atherosclerotic cardiovascular disease (ASCVD) is a major cause of mortality worldwide. This study aims to investigate the relationship between the 10-year ASCVD risk score and mental disorders.This study analyzed data from 1154 participants aged 25 to 70 enrolled in the Shiraz Heart Study cohort between 2016 and 2019. The ten-year ASCVD risk score was estimated using the ASCVD risk score estimator recommended by the American College of Cardiology and American Heart Association guidelines. Mental health was evaluated using a 28-item general health questionnaire concurrently with the ASCVD risk calculation. A multiple logistic regression model was employed for multivariate analysis. The mean age of participants was 44.25 ± 8.88 years, and most were men (n = 621, 53.8%). A multiple logistic regression model demonstrated that having ASCVD is associated with increased odds of somatic symptoms (OR 1.138, 95% CI 1.069–1.212), anxiety and insomnia (OR 1.113, 95% CI 1.043–1.188), severe depression (OR 1.173, 95% CI 1.084–1.269), and total general health scores (OR 1.053, CI 1.027–1.079). Another multiple logistic regression model showed that among participants without ASCVD, 10-year ASCVD risk score ≥ 5% is associated with increased odds of somatic symptoms (OR 1.126 95%CI 1.035–1.224), anxiety and insomnia (OR 1.117, 95% CI 1.031–1.211), social dysfunction (OR 1.121, 95% CI 1.034–1.215), severe depression (OR 1.195, 95% CI 1.078–1.324), and total general health scores (OR 1.068, CI 1.035–1.102). ASCVD and a 10-year ASCVD risk score ≥ 5 are associated with the development of mental disorders.