Scholarlink

<p>Autoimmunity is one of the potential mechanisms that has been proposed in the etiopathogenesis of chronic spontaneous urticaria (CSU). High serum zonulin levels are considered a marker for increased intestinal permeability, which has recently become an important research topic in autoimmune diseases. We designed this study to investigate the relationship between CSU and intestinal permeability based on serum zonulin levels. 65 patients with CSU and 65 age- and sex-matched healthy volunteers were included in the study. Serum zonulin levels were measured simultaneously with enzyme-linked immunosorbent assay (ELISA). Disease activity was assessed with the 7-day Urticaria Activity Score (UAS-7). The mean serum zonulin level was significantly higher in patients with chronic spontaneous urticaria (131.7 ± 49.7 pg/ml vs. 82.8 ± 29.4 pg/ml, <i>p</i> &lt; 0.001). Patients with chronic spontaneous urticaria who had concomitant inducible urticaria exhibited higher serum zonulin levels compared with those without inducible urticaria (p = 0.014). No significant correlation was found between serum zonulin levels and age, sex, body mass index, disease duration, concomitant angioedema, and UAS-7 score. The study found that patients with CSU had significantly elevated serum zonulin levels compared to healthy controls, supporting the hypothesis that urticaria is associated with increased intestinal permeability.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Chronic spontaneous urticaria is associated with elevated serum zonulin levels

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月20日

查看全文
  • Büşra Solak Esen,
  • Merve Hatun Erkayman

摘要

Autoimmunity is one of the potential mechanisms that has been proposed in the etiopathogenesis of chronic spontaneous urticaria (CSU). High serum zonulin levels are considered a marker for increased intestinal permeability, which has recently become an important research topic in autoimmune diseases. We designed this study to investigate the relationship between CSU and intestinal permeability based on serum zonulin levels. 65 patients with CSU and 65 age- and sex-matched healthy volunteers were included in the study. Serum zonulin levels were measured simultaneously with enzyme-linked immunosorbent assay (ELISA). Disease activity was assessed with the 7-day Urticaria Activity Score (UAS-7). The mean serum zonulin level was significantly higher in patients with chronic spontaneous urticaria (131.7 ± 49.7 pg/ml vs. 82.8 ± 29.4 pg/ml, p < 0.001). Patients with chronic spontaneous urticaria who had concomitant inducible urticaria exhibited higher serum zonulin levels compared with those without inducible urticaria (p = 0.014). No significant correlation was found between serum zonulin levels and age, sex, body mass index, disease duration, concomitant angioedema, and UAS-7 score. The study found that patients with CSU had significantly elevated serum zonulin levels compared to healthy controls, supporting the hypothesis that urticaria is associated with increased intestinal permeability.