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<p>Preterm children are more likely to experience neurodevelopmental challenges than neonates born at term. Early biomarkers of brain development may help clinicians to identify children in need of early interventions. The main objective of this study was to assess the associations between postnatal cerebral oxygen availability and utilization with neurodevelopmental outcome in preterm infants and explore sex-specific differences. This prospective observational cohort included 227 infants born at 29–36 weeks of gestation who underwent bedside optical neuromonitoring around term-equivalent age to measure cerebral oxygen availability (blood flow and delivery [CDO<sub>2i</sub>]) and utilization (metabolism [CMRO<sub>2i</sub>] and extraction fraction [OEF]). Neurodevelopmental outcome was assessed at 2 years corrected age. Linear regression analyses were used to assess the associations between neuromonitoring parameters and neurodevelopmental scores. Increased CDO<sub>2i</sub>, CMRO<sub>2i</sub> and OEF were associated with higher cognitive and language scores. When stratifying by sex, most of these associations were stronger in males than females. Associations between neuromonitoring parameters and motor scores were observed only in males. These results support the potential role of bedside optical neuromonitoring to provide early biomarkers of brain health and maturation in preterm infants and suggest sex-specific developmental mechanisms, which may indicate higher vulnerability in males.</p>

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Associations between postnatal cerebral oxygen availability and utilization in very to late preterm infants and neurodevelopmental outcome

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月11日

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  • Anurudhya Karthikeyan,
  • Thuy Mai Luu,
  • Rasheda Chowdhury,
  • Ramy El-Jalbout,
  • Mi-Suk Kang Dufour,
  • Olivia Beaulieu,
  • Léanne Brabant,
  • Gabriel Côté-Corriveau,
  • Marie-Michèle Gagnon,
  • Mélanie Gagnon,
  • Catherine Bernard,
  • Véronique Belval,
  • Anne-Monique Nuyt,
  • Marie-Noëlle Simard,
  • Mathieu Dehaes

摘要

Preterm children are more likely to experience neurodevelopmental challenges than neonates born at term. Early biomarkers of brain development may help clinicians to identify children in need of early interventions. The main objective of this study was to assess the associations between postnatal cerebral oxygen availability and utilization with neurodevelopmental outcome in preterm infants and explore sex-specific differences. This prospective observational cohort included 227 infants born at 29–36 weeks of gestation who underwent bedside optical neuromonitoring around term-equivalent age to measure cerebral oxygen availability (blood flow and delivery [CDO2i]) and utilization (metabolism [CMRO2i] and extraction fraction [OEF]). Neurodevelopmental outcome was assessed at 2 years corrected age. Linear regression analyses were used to assess the associations between neuromonitoring parameters and neurodevelopmental scores. Increased CDO2i, CMRO2i and OEF were associated with higher cognitive and language scores. When stratifying by sex, most of these associations were stronger in males than females. Associations between neuromonitoring parameters and motor scores were observed only in males. These results support the potential role of bedside optical neuromonitoring to provide early biomarkers of brain health and maturation in preterm infants and suggest sex-specific developmental mechanisms, which may indicate higher vulnerability in males.