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<p>Colorectal cancer is a leading cause of cancer-related mortality, and accurate analysis of histopathological images is critical for early diagnosis and improved patient outcomes. This study proposes and systematically evaluates four purpose-built lightweight convolutional neural network (CNN) variants (Lite-V0, Lite-V1, Lite-V2, and Lite-V4) for binary classification of colon histopathology images into <i>Colon_Adenocarcinoma</i> and <i>Colon_Benign_Tissue</i>. Experiments were conducted on a balanced dataset (24,000 images) with fixed train/validation/test splits and comprehensive evaluation using accuracy and macro-F1, supported by confusion matrices and ROC/precision–recall analyses. Among all variants, Lite-V2 achieved the best validation performance (macro-F1 <InlineEquation ID="IEq1"> <EquationSource Format="TEX">\(\approx\)</EquationSource> </InlineEquation> 0.999), while remaining highly compact (1.53 MB; 127,682 parameters), indicating a favorable accuracy–efficiency trade-off for deployment-oriented diagnostic support. On the independent test set, however, Lite-V2 exhibited a marked generalization drop, achieving approximately 50% accuracy and macro-F1 = 0.33, suggesting a domain-shift effect between validation and test samples. These findings demonstrate that lightweight CNNs can achieve near-perfect internal validation performance for colon histopathology classification, but robust cross-domain generalization remains essential; future work will focus on domain adaptation and stain-robust training strategies to improve reliability on unseen clinical data.</p>

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Compact deep learning models for colon histopathology focusing performance and generalization challenges

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月19日

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  • Fareeha Hanif,
  • Ali Raza,
  • Heba Abdelgader Mohammed

摘要

Colorectal cancer is a leading cause of cancer-related mortality, and accurate analysis of histopathological images is critical for early diagnosis and improved patient outcomes. This study proposes and systematically evaluates four purpose-built lightweight convolutional neural network (CNN) variants (Lite-V0, Lite-V1, Lite-V2, and Lite-V4) for binary classification of colon histopathology images into Colon_Adenocarcinoma and Colon_Benign_Tissue. Experiments were conducted on a balanced dataset (24,000 images) with fixed train/validation/test splits and comprehensive evaluation using accuracy and macro-F1, supported by confusion matrices and ROC/precision–recall analyses. Among all variants, Lite-V2 achieved the best validation performance (macro-F1 \(\approx\) 0.999), while remaining highly compact (1.53 MB; 127,682 parameters), indicating a favorable accuracy–efficiency trade-off for deployment-oriented diagnostic support. On the independent test set, however, Lite-V2 exhibited a marked generalization drop, achieving approximately 50% accuracy and macro-F1 = 0.33, suggesting a domain-shift effect between validation and test samples. These findings demonstrate that lightweight CNNs can achieve near-perfect internal validation performance for colon histopathology classification, but robust cross-domain generalization remains essential; future work will focus on domain adaptation and stain-robust training strategies to improve reliability on unseen clinical data.