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<p>The persisting SARS-CoV-2 genetic mutation could unintentionally increase human transmission, mortality, and aggravation. Since no specific pharmaceutical therapies or vaccinations exist, rapid detection and successful treatment are essential for managing the COVID-19 pandemic. BioTFETs exhibit superior sensitivity and faster response times than bioFETs, which are more vulnerable to substantial subthreshold swing and short-channel effects. This article presents the Dielectrically Modulated-Double Gate-Heterojunction-Tunnel FET-based biosensor (DG-bioHTFET) specifically engineered to identify and detect the nucleocapsid protein and RNA biomolecules with specific permittivity (k) of SARS-CoV-2 biomolecules embedded in the nanogaps. At V<sub>gs</sub> = 1.5&#xa0;V, the proposed device achieves a drain current (I<sub>ds</sub>) of 2.32 × 10<sup>− 5</sup> A/µm. At k = 5 and k = 3.64, the I<sub>ON</sub>/I<sub>OFF</sub> ratios are 3.550 × 10<sup>5</sup> and 3.403 × 10<sup>5</sup>, respectively. The data suggest that the device exhibits increased sensitivity to biomolecules possessing elevated dielectric constants. It is feasible to design ultra-sensitive TFET biosensors as a bio-recognition unit, which offers the benefits of rapid label-free detection and high sensitivity. The device exhibits superior performance in terms of high drain current with enhanced sensitivity for precise biosensing applications.</p>

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Ultra-sensitive heterojunction double gate BioTFET device for SARS-CoV-2 biomolecules detection

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年4月30日

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  • P. Vimala,
  • A. Sharon Geege,
  • N. Mohankumar,
  • T. S. Arun Samuel,
  • T. Ananth Kumar,
  • P. Suveetha Dhanaselvam,
  • I. Vivek Anand

摘要

The persisting SARS-CoV-2 genetic mutation could unintentionally increase human transmission, mortality, and aggravation. Since no specific pharmaceutical therapies or vaccinations exist, rapid detection and successful treatment are essential for managing the COVID-19 pandemic. BioTFETs exhibit superior sensitivity and faster response times than bioFETs, which are more vulnerable to substantial subthreshold swing and short-channel effects. This article presents the Dielectrically Modulated-Double Gate-Heterojunction-Tunnel FET-based biosensor (DG-bioHTFET) specifically engineered to identify and detect the nucleocapsid protein and RNA biomolecules with specific permittivity (k) of SARS-CoV-2 biomolecules embedded in the nanogaps. At Vgs = 1.5 V, the proposed device achieves a drain current (Ids) of 2.32 × 10− 5 A/µm. At k = 5 and k = 3.64, the ION/IOFF ratios are 3.550 × 105 and 3.403 × 105, respectively. The data suggest that the device exhibits increased sensitivity to biomolecules possessing elevated dielectric constants. It is feasible to design ultra-sensitive TFET biosensors as a bio-recognition unit, which offers the benefits of rapid label-free detection and high sensitivity. The device exhibits superior performance in terms of high drain current with enhanced sensitivity for precise biosensing applications.