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<p>S-methyl thioesters have proven to be useful intermediates in many biosynthetic reactions and their occurrence in bioactive molecules further enhance their appeal. Shortcomings in several reported synthetic protocols have led us to disclose herewith a mild, room temperature ex situ protocol that provides access to a large number of thioesters (aryl, heteroaryl, alkyl, amino acids). Late-stage functionalization strategies were also performed on commercial pharmaceutical drugs (containing carboxylic acid functionality) while further in situ conversion to valuable compounds has also been achieved.</p>

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Room temperature, metal-free, CDI-promoted, ex-situ protocol for S-methyl thioester synthesis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月27日

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  • Manisha A. Patel,
  • Vandana Sharma,
  • Rupali Chavan,
  • Juhi Pal,
  • Santosh J. Gharpure,
  • Anant R. Kapdi

摘要

S-methyl thioesters have proven to be useful intermediates in many biosynthetic reactions and their occurrence in bioactive molecules further enhance their appeal. Shortcomings in several reported synthetic protocols have led us to disclose herewith a mild, room temperature ex situ protocol that provides access to a large number of thioesters (aryl, heteroaryl, alkyl, amino acids). Late-stage functionalization strategies were also performed on commercial pharmaceutical drugs (containing carboxylic acid functionality) while further in situ conversion to valuable compounds has also been achieved.