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<p>This study aims to develop an innovative drug delivery bio-system using bioglass (BIOGLASS) and biopolymers of Sodium Alginate (SA) and polyvinylpyrrolidone (PVP) in microsphere form as a carrier for Amoxicillin/Clavulanic Acid drug. In this work BIOGLASS/SA-PVP and Amoxicillin/Clavulanic Acid loaded BIOGLASS/SA-PVP microspheres (0%, 5%, 10%, and 15%) were synthesized using the ion crosslinking method technique. The fabricated microspheres were analyzed using FT-IR, FESEM/EDX, and XRD confirming the <i>in-vitro</i> examination. XRD and FTIR data demonstrate the effective creation of the apatite layer and the appearance of new apatite peaks at both 605&#xa0;cm<sup>−1</sup> and 565&#xa0;cm<sup>−1</sup>, distinguishing the prolonged vibrations associated with the <InlineEquation ID="IEq1"> <InlineMediaObject> <ImageObject Color="BlackWhite" FileRef="41598_2025_96590_Article_IEq1.gif" Format="GIF" Height="21" Rendition="HTML" Resolution="72" Type="Linedraw" Width="40" /> </InlineMediaObject> <EquationSource Format="TEX">\({\text{PO}}_{4}^{-3}\)</EquationSource> </InlineEquation> group. SEM images reveal that the prepared bio-beads have a spherical shape, with sizes falling in the micro-scale. The dielectric constant (εʹ), the dielectric loss (εʺ), and the AC conductivity (σ) were slow at the frequency range of 4&#xa0;Hz to 8&#xa0;MHz at room temperature. The antibacterial examinations of the fabricated microspheres were performed employing agar diffusion procedure against the clinical pathogens Gram<sup>+</sup> and Gram<sup>-</sup> bacteria. The SBF (simulated body fluid) experiments display the formation of a hydroxy appetite coating on the microsphere’s surfaces that approves their significant bioactivity. Furthermore, antimicrobial results of BIOGLASS/SA-PVP/Amoxicillin/Clavulanic Acid microspheres reveal a notable impact on the antimicrobial performance. The <i>in-vitro</i> tests established that fabricated bio-microspheres are a promising opportunity for bone tissue engineering (substitutes and regeneration), signifying their promise for bone application.</p>

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Exploring of spectroscopic, dielectric, and bioactivity performance of bioglass/sodium alginate-PVP loaded-Amoxicillin/Clavulanic Acid microspheres for bone tissue engineering

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月2日

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  • Ahmed M. Bakr,
  • Amany M. El Nahrawy,
  • A. M. Mansour,
  • Ali B. Abou Hammad

摘要

This study aims to develop an innovative drug delivery bio-system using bioglass (BIOGLASS) and biopolymers of Sodium Alginate (SA) and polyvinylpyrrolidone (PVP) in microsphere form as a carrier for Amoxicillin/Clavulanic Acid drug. In this work BIOGLASS/SA-PVP and Amoxicillin/Clavulanic Acid loaded BIOGLASS/SA-PVP microspheres (0%, 5%, 10%, and 15%) were synthesized using the ion crosslinking method technique. The fabricated microspheres were analyzed using FT-IR, FESEM/EDX, and XRD confirming the in-vitro examination. XRD and FTIR data demonstrate the effective creation of the apatite layer and the appearance of new apatite peaks at both 605 cm−1 and 565 cm−1, distinguishing the prolonged vibrations associated with the \({\text{PO}}_{4}^{-3}\) group. SEM images reveal that the prepared bio-beads have a spherical shape, with sizes falling in the micro-scale. The dielectric constant (εʹ), the dielectric loss (εʺ), and the AC conductivity (σ) were slow at the frequency range of 4 Hz to 8 MHz at room temperature. The antibacterial examinations of the fabricated microspheres were performed employing agar diffusion procedure against the clinical pathogens Gram+ and Gram- bacteria. The SBF (simulated body fluid) experiments display the formation of a hydroxy appetite coating on the microsphere’s surfaces that approves their significant bioactivity. Furthermore, antimicrobial results of BIOGLASS/SA-PVP/Amoxicillin/Clavulanic Acid microspheres reveal a notable impact on the antimicrobial performance. The in-vitro tests established that fabricated bio-microspheres are a promising opportunity for bone tissue engineering (substitutes and regeneration), signifying their promise for bone application.