Scholarlink

<p>Depression and obesity are common chronic diseases in modern society. Meta-analyses consistently reveal a bidirectional relationship: individuals with depression have a higher risk of obesity, while obese individuals are more prone to depression. High-fat diet (HFD) consumption is a risk factor of obesity. However, the impact of depression on obesity and the underlying mechanisms remains unclear. We aim to assess the impact of a long-term depressive state throughout adulthood on body weight changes induced by HFD, and whether HFD affects depressive state in mice. We established a depression mouse model using a Chronic Unpredictable Mild Stress&#xa0;(CUMS) paradigm. Following the stress period, male mice were fed with a normal diet or a HFD for seven weeks prior to behavioral tests and body weight measurements. Our results suggest that exposure to CUMS initially accelerated weight gain in mice; however, it did not significantly affect final body weight or white adipose tissue weight. Additionally, while HFD did not significantly impact measures of depression-like behavior in CUMS mice but tended to induce depression-like behavior in control mice. Overall, contrary to clinical observations, our findings revealed that a depressive state did not significantly affect the development of obesity in mice, nor did HFD significantly exacerbate depressive-like behaviors in mice.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Interaction between depressive state and high-fat diet and its impact on behavioral and body weight changes in male mice

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年4月9日

查看全文
  • Juntao Hu,
  • Xiaojie Li,
  • Muyang Tang,
  • Mitchell Wan,
  • Shanshan Zhang,
  • Haoran Wu,
  • Meihui Li,
  • Leilei Wang,
  • Honglei Xiao,
  • Min Zhu,
  • Xinxia Chang,
  • Qiong Liu

摘要

Depression and obesity are common chronic diseases in modern society. Meta-analyses consistently reveal a bidirectional relationship: individuals with depression have a higher risk of obesity, while obese individuals are more prone to depression. High-fat diet (HFD) consumption is a risk factor of obesity. However, the impact of depression on obesity and the underlying mechanisms remains unclear. We aim to assess the impact of a long-term depressive state throughout adulthood on body weight changes induced by HFD, and whether HFD affects depressive state in mice. We established a depression mouse model using a Chronic Unpredictable Mild Stress (CUMS) paradigm. Following the stress period, male mice were fed with a normal diet or a HFD for seven weeks prior to behavioral tests and body weight measurements. Our results suggest that exposure to CUMS initially accelerated weight gain in mice; however, it did not significantly affect final body weight or white adipose tissue weight. Additionally, while HFD did not significantly impact measures of depression-like behavior in CUMS mice but tended to induce depression-like behavior in control mice. Overall, contrary to clinical observations, our findings revealed that a depressive state did not significantly affect the development of obesity in mice, nor did HFD significantly exacerbate depressive-like behaviors in mice.