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<p>TAS2R38 is the T2R receptor primarily associated with the innate immune response of the respiratory system. It activates a response mediated by nitric oxide (NO), which has been shown to inhibit the replication of SARS-CoV-2. <i>TAS2R38</i> polymorphisms (SNPs) that decrease receptor functionality contributing to individual differences in susceptibility to airway infections. DNA methylation (DNAm) may affect gene expression influencing disease development, including COVID-19. We analyzed the effect of SARS-CoV-2 on the methylation pattern of <i>TAS2R38</i> (at cg25481253, a CpG site located in the coding region) during infection and after the cessation of the exposure to the virus, also considering the disease severity and <i>TAS2R38</i> SNPs. Our results showed a positive relationship between <i>TAS2R38</i> DNAm levels and disease severity in the COVID-19 patients and a return to a normal state after the infection. In addition, our results showed an association between DNAm level and the TAS2R38 genotype in participants who recovered from the disease. PAV/PAV genotypes showed lower <i>TAS2R38</i> DNAm levels than heterozygous and AVI homozygous. In conclusion, our results clearly indicate the involvement of <i>TAS2R38</i> DNAm alteration in COVID-19 severity and suggest a role of the methylation changes at cg25481253 in the regulation of the <i>TAS2R38</i> expression.</p>

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TAS2R38 gene methylation is associated with syndrome Coronavirus 2 (SARS-CoV-2) infection and clinical symptoms

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年4月25日

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  • Melania Melis,
  • Eleonora Loi,
  • Giacomo Aru,
  • Giorgia Sollai,
  • Mariano Mastinu,
  • Lala Chaimae Naciri,
  • Giacomo De Riu,
  • Luigi Angelo Vaira,
  • Giulia Costanzo,
  • Davide Firinu,
  • Paola Cabras,
  • Aldo Caddori,
  • Roberto Crnjar,
  • Patrizia Zavattari,
  • Iole Tomassini Barbarossa

摘要

TAS2R38 is the T2R receptor primarily associated with the innate immune response of the respiratory system. It activates a response mediated by nitric oxide (NO), which has been shown to inhibit the replication of SARS-CoV-2. TAS2R38 polymorphisms (SNPs) that decrease receptor functionality contributing to individual differences in susceptibility to airway infections. DNA methylation (DNAm) may affect gene expression influencing disease development, including COVID-19. We analyzed the effect of SARS-CoV-2 on the methylation pattern of TAS2R38 (at cg25481253, a CpG site located in the coding region) during infection and after the cessation of the exposure to the virus, also considering the disease severity and TAS2R38 SNPs. Our results showed a positive relationship between TAS2R38 DNAm levels and disease severity in the COVID-19 patients and a return to a normal state after the infection. In addition, our results showed an association between DNAm level and the TAS2R38 genotype in participants who recovered from the disease. PAV/PAV genotypes showed lower TAS2R38 DNAm levels than heterozygous and AVI homozygous. In conclusion, our results clearly indicate the involvement of TAS2R38 DNAm alteration in COVID-19 severity and suggest a role of the methylation changes at cg25481253 in the regulation of the TAS2R38 expression.