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<p>Choline salicylate [Ch][Sal] an active pharmaceutical ingredient ionic liquid (API-IL) aqueous solutions in the presence of <i>L</i>-glycine that is a simple simulated biological media has been studied. The thermodynamic and transport properties including density, speed of sound, viscosity and electrical conductance have been studied under atmospheric pressure and a temperature range of (288.15 to 318.15) K. The key thermophysical properties, including apparent molar volume (<i>V</i><sub><i>φ</i></sub>), apparent molar isentropic compressibility (<i>κ</i><sub><i>φ</i></sub>), viscosity <i>B</i>-coefficient, ion association constant (<i>K</i><sub><i>a</i></sub>), and limiting molar conductivity (<i>Λ</i><sub><i>0</i></sub>) were derived from these data. The transfer properties (<i>Δ</i><sub><i>tr</i></sub><i>V</i><sub><i>φ</i></sub><sup><i>0</i></sup>, <i>Δ</i><sub><i>tr</i></sub><i>κ</i><sub><i>φ</i></sub><sup><i>0</i></sup>, and <i>ΔB</i><sub><i>tr</i></sub>) demonstrate the dominance hydrophilic-hydrophilic interactions between the IL and <i>L</i>-glycine in the studied systems that increased with <i>L</i>-glycine concentration. The COSMO results revealed that differences in molecular size, stability, and hydration behavior of [Ch][Sal] and <i>L</i>-glycine, with [Ch][Sal] exhibiting stronger hydration due to its larger size and hydrogen bonding capacity. These findings provide insights into solute-solvent interactions and potential synergistic effects of [Ch][Sal] and <i>L</i>-glycine as a simple simulated biological media contributing to the optimization of pharmaceutical formulations and related activities.</p>

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Theoretical and experimental investigation of hydration behavior of choline salicylate ionic liquid in the presence of L- glycine

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年4月22日

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  • Negin Ammari,
  • Hemayat Shekaari,
  • Behrang Golmohammadi,
  • Fariba Ghaffari,
  • Mohammed Taghi Zafarani-Moattar

摘要

Choline salicylate [Ch][Sal] an active pharmaceutical ingredient ionic liquid (API-IL) aqueous solutions in the presence of L-glycine that is a simple simulated biological media has been studied. The thermodynamic and transport properties including density, speed of sound, viscosity and electrical conductance have been studied under atmospheric pressure and a temperature range of (288.15 to 318.15) K. The key thermophysical properties, including apparent molar volume (Vφ), apparent molar isentropic compressibility (κφ), viscosity B-coefficient, ion association constant (Ka), and limiting molar conductivity (Λ0) were derived from these data. The transfer properties (ΔtrVφ0, Δtrκφ0, and ΔBtr) demonstrate the dominance hydrophilic-hydrophilic interactions between the IL and L-glycine in the studied systems that increased with L-glycine concentration. The COSMO results revealed that differences in molecular size, stability, and hydration behavior of [Ch][Sal] and L-glycine, with [Ch][Sal] exhibiting stronger hydration due to its larger size and hydrogen bonding capacity. These findings provide insights into solute-solvent interactions and potential synergistic effects of [Ch][Sal] and L-glycine as a simple simulated biological media contributing to the optimization of pharmaceutical formulations and related activities.