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<p> <?tk 2?>Eastern Cooperative Oncology Group performance status (ECOG-PS) is a widely used functional status measure in oncology, yet its prognostic value in upper tract urothelial carcinoma remains unclear. In this multicenter study of 2473 patients undergoing radical nephroureterectomy, ECOG-PS ≥ 2 was independently associated with worse overall survival (hazard ratio [HR] 2.53, <i>p</i> &lt; 0.001), cancer-specific survival (HR 2.02, <i>p</i> &lt; 0.001), and disease-free survival (HR 1.50, <i>p</i> = 0.003) than those with ECOG-PS 0–1. They also had a higher risk of major perioperative complications (odds ratio 2.46, <i>p</i> &lt; 0.001). These findings support ECOG-PS as a valuable preoperative risk stratification tool.</p>

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Preoperative ECOG performance status as a predictor of outcomes in upper tract urothelial cancer surgery

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月26日

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  • Tsung-Mu Yang,
  • I-Hsuan Alan Chen,
  • Chia-Cheng Yu,
  • Chi-Rei Yang,
  • Wen-Chi Chen,
  • Po-Hung Lin,
  • See-Tong Pang,
  • Steven Kuan-Hua Huang,
  • Zhi‐Hao Chen,
  • Jen-Shu Tseng,
  • Wun-Rong Lin,
  • Yao-Chou Tsai,
  • Chih-Chin Yu,
  • Pi-Che Chen,
  • Ian-Seng Cheong,
  • Yuan-Hong Jiang,
  • Chia-Chang Wu,
  • Hsu-Che Huang,
  • Ting-En Tai,
  • Chung-You Tsai,
  • Wei-Yu Lin,
  • Yung-Tai Chen,
  • Richard Chen-Yu Wu,
  • Hsiang-Ying Lee,
  • Hsin-Chih Yeh

摘要

Eastern Cooperative Oncology Group performance status (ECOG-PS) is a widely used functional status measure in oncology, yet its prognostic value in upper tract urothelial carcinoma remains unclear. In this multicenter study of 2473 patients undergoing radical nephroureterectomy, ECOG-PS ≥ 2 was independently associated with worse overall survival (hazard ratio [HR] 2.53, p < 0.001), cancer-specific survival (HR 2.02, p < 0.001), and disease-free survival (HR 1.50, p = 0.003) than those with ECOG-PS 0–1. They also had a higher risk of major perioperative complications (odds ratio 2.46, p < 0.001). These findings support ECOG-PS as a valuable preoperative risk stratification tool.