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<p>Jaw1/LRMP/IRAG2 enhances Ca<sup>2+</sup> release via interaction with inositol 1,4,5-trisphosphate receptors (ITPRs), Ca<sup>2+</sup> channels on the endoplasmic reticulum, upon G protein-coupled receptor stimulation. While our previous works demonstrated the increases in the maximum amplitude and retention time of the Ca<sup>2+</sup> curve with heterogeneous effects on each ITPR subtype: ITPR1, ITPR2, and ITPR3, the effects on the reaction speed remain unclear. In this study, we unveiled the additional roles of Jaw1 in accelerating the signal onset time and rise time to the first peak top, especially in the cells expressing ITPR1. These findings shed more light on the relationship between the expression pattern of Jaw1 and ITPRs, and the heterogeneous pattern of the Ca<sup>2+</sup> dynamics, offering insights into their physiological implications.</p>

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Jaw1 accelerates the reaction speed of the Ca2+ signals via ITPRs upon GPCR stimulation

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月24日

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  • Takuma Kozono,
  • Hitomi Matsui,
  • Marielle Fernandez Bandalan,
  • Takashi Tonozuka,
  • Atsushi Nishikawa

摘要

Jaw1/LRMP/IRAG2 enhances Ca2+ release via interaction with inositol 1,4,5-trisphosphate receptors (ITPRs), Ca2+ channels on the endoplasmic reticulum, upon G protein-coupled receptor stimulation. While our previous works demonstrated the increases in the maximum amplitude and retention time of the Ca2+ curve with heterogeneous effects on each ITPR subtype: ITPR1, ITPR2, and ITPR3, the effects on the reaction speed remain unclear. In this study, we unveiled the additional roles of Jaw1 in accelerating the signal onset time and rise time to the first peak top, especially in the cells expressing ITPR1. These findings shed more light on the relationship between the expression pattern of Jaw1 and ITPRs, and the heterogeneous pattern of the Ca2+ dynamics, offering insights into their physiological implications.