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<p>Fucoidan is a fucose-rich sulfated polysaccharide that has gained attention owing to its various biological activities. In this study, fucoidan was isolated from <i>Saccharina japonica</i> using an enzyme-assisted method, and its antioxidant and anti-hepatocarcinoma effects were evaluated. The fucoidan was a 112.8&#xa0;kDa polysaccharide comprising seven monosaccharides: fucose, xylose, glucuronic acid, rhamnose, glucose, mannose, and galactose. The main chain residues were (1 → 3)-α-L-Fuc<i>p</i> and (1 → 4)-α-L-Fuc<i>p</i> units with sulfate groups at the C-2/C-4 positions of the (1 → 3)-α-L-Fuc<i>p</i> residues. <i>S. japonica</i> fucoidans showed excellent antioxidant potency with values of 1.02&#xa0;mg TE/g and 5.39&#xa0;mg TE/g for the ABTS and FRAP assays, respectively. Additionally, they exerted antitumor efficacy and low systemic toxicity in H22 tumor-bearing mice, with a tumor inhibition rate of 42.93%. Furthermore, it significantly inhibited tumor angiogenesis and reduced pro-inflammatory cytokines levels (IL-1β, IL-6, and TNF-α). Our results suggest that fucoidan isolated from <i>S. japonica</i> possesses potent antioxidant and anticancer properties and may be used as a potential agent for hepatocellular carcinoma treatment.</p>

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Antioxidant and anticancer properties of fucoidan isolated from Saccharina Japonica brown algae

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月15日

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  • Qiulin Yue,
  • Yongxuan Liu,
  • Fujia Li,
  • Tao Hong,
  • Shousen Guo,
  • Mengrui Cai,
  • Lin Zhao,
  • Le Su,
  • Song Zhang,
  • Chen Zhao,
  • Kunlun Li

摘要

Fucoidan is a fucose-rich sulfated polysaccharide that has gained attention owing to its various biological activities. In this study, fucoidan was isolated from Saccharina japonica using an enzyme-assisted method, and its antioxidant and anti-hepatocarcinoma effects were evaluated. The fucoidan was a 112.8 kDa polysaccharide comprising seven monosaccharides: fucose, xylose, glucuronic acid, rhamnose, glucose, mannose, and galactose. The main chain residues were (1 → 3)-α-L-Fucp and (1 → 4)-α-L-Fucp units with sulfate groups at the C-2/C-4 positions of the (1 → 3)-α-L-Fucp residues. S. japonica fucoidans showed excellent antioxidant potency with values of 1.02 mg TE/g and 5.39 mg TE/g for the ABTS and FRAP assays, respectively. Additionally, they exerted antitumor efficacy and low systemic toxicity in H22 tumor-bearing mice, with a tumor inhibition rate of 42.93%. Furthermore, it significantly inhibited tumor angiogenesis and reduced pro-inflammatory cytokines levels (IL-1β, IL-6, and TNF-α). Our results suggest that fucoidan isolated from S. japonica possesses potent antioxidant and anticancer properties and may be used as a potential agent for hepatocellular carcinoma treatment.