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<p>In recent years, the widespread use of antibiotics has led to the emergence of numerous drug-resistant bacteria, posing a severe threat to both human health and the economy. As a result, it is imperative to develop efficient antibacterial agents that do not induce drug resistance. This study employed layer-by-layer assembly technology to prepare ZnFe<sub>2</sub>O<sub>4</sub>@ZnS/Cu<sub>2</sub>S (ZZC) nanocomposites Gram-negative <i>Escherichia coli</i> (<i>E. coli</i>), Gram-positive <i>Staphylococcus aureus</i> (<i>S. aureus</i>) and drug-resistant <i>Salmonella</i> (<i>T-Salmonella</i>) were utilized as test bacteria to investigate the antibacterial effectiveness and mechanism of ZZC. The findings demonstrated that, the MIC of the ZZC against <i>E. coli</i>, <i>S. aureus</i> and <i>T-Salmonella</i> were 50, 60 and 80&#xa0;μg/mL, respectively; At a material concentration of 200&#xa0;μg/mL and a reaction time of 80&#xa0;min, ZZC demonstrated a bacteriostatic rate of 99.99% against the three tested bacteria. The nano-composite can disrupt cell walls and plasma membranes and effectively and resulting in bacterial rupture and demise. Furthermore, the nano-composite displayed strong biocompatibility and was also able to heal mixed bacterial-induced wound infections and essentially eliminated the bacterial burden after 9&#xa0;days, and also exhibited excellent antimicrobial activity in vivo. The results also indicate significant potential for its application in medical materials and other areas of research.</p>

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Study of antibacterial activity of copper zinc nanocomposites and disruption of bacterial cytoplasmic membrane

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月23日

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  • Zhongshang Guo,
  • Huihui Chen,
  • Ruiling Hu,
  • Jiawei Wang,
  • Miao Wu,
  • Yinghua Wu,
  • Tinghui Qiang,
  • Huan Mou,
  • Xingguo Du,
  • Fei Gao,
  • Shaobo Guo,
  • Xinli Zhou

摘要

In recent years, the widespread use of antibiotics has led to the emergence of numerous drug-resistant bacteria, posing a severe threat to both human health and the economy. As a result, it is imperative to develop efficient antibacterial agents that do not induce drug resistance. This study employed layer-by-layer assembly technology to prepare ZnFe2O4@ZnS/Cu2S (ZZC) nanocomposites Gram-negative Escherichia coli (E. coli), Gram-positive Staphylococcus aureus (S. aureus) and drug-resistant Salmonella (T-Salmonella) were utilized as test bacteria to investigate the antibacterial effectiveness and mechanism of ZZC. The findings demonstrated that, the MIC of the ZZC against E. coli, S. aureus and T-Salmonella were 50, 60 and 80 μg/mL, respectively; At a material concentration of 200 μg/mL and a reaction time of 80 min, ZZC demonstrated a bacteriostatic rate of 99.99% against the three tested bacteria. The nano-composite can disrupt cell walls and plasma membranes and effectively and resulting in bacterial rupture and demise. Furthermore, the nano-composite displayed strong biocompatibility and was also able to heal mixed bacterial-induced wound infections and essentially eliminated the bacterial burden after 9 days, and also exhibited excellent antimicrobial activity in vivo. The results also indicate significant potential for its application in medical materials and other areas of research.