<p>There is conflicting information about the association between egg intake and metabolic health status and no previous information on this association was found in Middle Eastern populations. This research aimed to investigate the relationship between egg consumption and metabolic health status in Iranian adults, focusing on the potential involvement of brain-derived neurotrophic factor (BDNF) and adropin.&#xa0;This cross-sectional study was done on a sample of 527 individuals (45.7% female) aged between 20 and 65&#xa0;years. Participants were selected using a multistage cluster random-sampling method. Dietary intakes of participants were evaluated using a validated food frequency questionnaire. Blood samples were collected while the individuals were fasting to assess biochemical markers. Metabolic health status of individuals was assessed based on the criteria established by Wildman. Collecting data on covariates was done using pre-tested procedures. Multivariable-adjusted model revealed a statistically significant association between egg consumption and a decreased odds of metabolically unhealthy (MU) status (OR_{T3 vs. T1} = 0.47; 95%CI 0.24–0.92). Also, each tertile increase in egg consumption was significantly associated with decreased odds of MU status (OR = 0.68; 95%CI 0.49–0.96). This association was especially significant among males rather than females. Elevated high-sensitive C-reactive protein (hs-CRP) levels were substantially reduced among individuals with the highest consumption of egg compared to the lowest intake. Additionally, there was a slight inverse association between egg consumption and high blood pressure. There were no relationships between egg intake and having low BDNF, and adropin levels. Increased consumption of egg was associated with a decreased chance of being metabolically unhealthy in Iranian adults, especially in male participants.</p>