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<p>Bioactive antimicrobial films play important roles in various fields, such as biodegradable interfaces, tissue regeneration, and biomedical applications where preventing infection, biocompatibility, and immune rejection are important. In the present study, bioactive POSS-doped Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene filled PLA composite film was prepared using the solution casting method for biomedical applications. The contact angle tests were investigated to reveal the usability of the thin films in biomedical applications. The angle decreased from 85.92° degrees in pure PLA thin films to 72.23° on POSS-doped Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene films. The antibacterial performance, cytotoxicity and cell viability assessments of the prepared films have also been thoroughly investigated. Antibacterial tests revealed that the POSS-doped Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene films effectively inhibited the growth of <i>E. coli</i> and <i>S. aureus</i> by 65.93% and 80.63%, respectively, within 4&#xa0;h. These inhibition rates were observed as 58.32% and 54.97% for <i>E. coli</i> and <i>S. aureus</i>, respectively, after 24&#xa0;h. Cytotoxicity assessments demonstrated that PMPs consistently showed higher cell viability due to the combination of POSS and Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene. The obtained results suggest that the POSS-doped Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene film is a promising candidate in cases where bacterial inhibition and high biocompatibility are of critical importance.</p>

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Cytotoxicity and antibacterial activity of polyhedral oligomeric silsesquioxane modified Ti3C2Tx MXene films

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月12日

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  • Yuksel Akinay,
  • Erkan Karatas,
  • Damla Ruzgar,
  • Ali Akbari,
  • Dilges Baskin,
  • Tayfun Cetin,
  • Hilal Celik Kazici,
  • Mehmet Topuz

摘要

Bioactive antimicrobial films play important roles in various fields, such as biodegradable interfaces, tissue regeneration, and biomedical applications where preventing infection, biocompatibility, and immune rejection are important. In the present study, bioactive POSS-doped Ti3C2Tx MXene filled PLA composite film was prepared using the solution casting method for biomedical applications. The contact angle tests were investigated to reveal the usability of the thin films in biomedical applications. The angle decreased from 85.92° degrees in pure PLA thin films to 72.23° on POSS-doped Ti3C2Tx MXene films. The antibacterial performance, cytotoxicity and cell viability assessments of the prepared films have also been thoroughly investigated. Antibacterial tests revealed that the POSS-doped Ti3C2Tx MXene films effectively inhibited the growth of E. coli and S. aureus by 65.93% and 80.63%, respectively, within 4 h. These inhibition rates were observed as 58.32% and 54.97% for E. coli and S. aureus, respectively, after 24 h. Cytotoxicity assessments demonstrated that PMPs consistently showed higher cell viability due to the combination of POSS and Ti3C2Tx MXene. The obtained results suggest that the POSS-doped Ti3C2Tx MXene film is a promising candidate in cases where bacterial inhibition and high biocompatibility are of critical importance.