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<p>Mitochondria absorb short wavelengths around 420&#xa0;nm. This is associated with reduced ATP and restricted mobility. The 420–450&#xa0;nm range is a significant element of LED lighting and computer monitors. Here we expose freely moving mice to 420–450&#xa0;nm lighting and show rapidly weight gain within a week. This may be due to reduced mitochondrial demand for circulating carbohydrates. Both groups displayed marked shifts in serum cytokines. Open field mobility was examined. The distance travelled was similar between both experimental groups and their controls. However, both experimental groups showed avoidance of central regions consistent with anxiety-like behaviours. This was significant in the 420&#xa0;nm group whose wavelength exposure is closer to peak mitochondrial absorbance. These data demonstrate the potential hazards of exposure to specific short wavelengths in the visual range now common in the built environment. Data are consistent with a wider literature on systemic problems arising from exposure to short wavelength light.</p>

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Impact of short wavelength light exposure on body weight, mobility, anxiety like behaviour and cytokine expression

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年2月18日

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  • Heba Al-Hussaini,
  • Mohammed Al-Onaizi,
  • Bara S. Abed,
  • Michael B. Powner,
  • Sonia M. Hasan,
  • Glen Jeffery

摘要

Mitochondria absorb short wavelengths around 420 nm. This is associated with reduced ATP and restricted mobility. The 420–450 nm range is a significant element of LED lighting and computer monitors. Here we expose freely moving mice to 420–450 nm lighting and show rapidly weight gain within a week. This may be due to reduced mitochondrial demand for circulating carbohydrates. Both groups displayed marked shifts in serum cytokines. Open field mobility was examined. The distance travelled was similar between both experimental groups and their controls. However, both experimental groups showed avoidance of central regions consistent with anxiety-like behaviours. This was significant in the 420 nm group whose wavelength exposure is closer to peak mitochondrial absorbance. These data demonstrate the potential hazards of exposure to specific short wavelengths in the visual range now common in the built environment. Data are consistent with a wider literature on systemic problems arising from exposure to short wavelength light.