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<p>Metabolic Associated Fatty Liver Disease (MAFLD) is becoming a major global health concern due to its links with obesity, insulin resistance, and cardiovascular risk. This randomized clinical trial assessed the effects of combining time-restricted feeding (TRF; 16/8) with a Lacto-Ovo-Vegetarian (LOV) diet on various factors in overweight and obese patients with MAFLD. Forty-six participants were randomly assigned to either the intervention group (TRF with LOV diet) or the control group, with 21 participants completing the 12-week study in each group. The intervention group showed significant reductions in weight (-8.07 ± 4.31&#xa0;kg), BMI (-2.70 ± 1.32&#xa0;kg/m<sup>2</sup>), waist circumference (-8.00 ± 4.06&#xa0;cm), as well as ALT (-17.14 ± 14.33 U/L), GGT (-21.09 ± 24.06 U/L), Fatty Liver Index (-26.90 ± 15.81), insulin levels (-3.89 ± 4.69 mU/L), and TNF-α (-11.85 ± 12.52 pg/mL) compared to the control group (all <i>P</i> &lt; 0.05). Lipid profiles also improved with a reduction in triglycerides (-46.85 ± 54.55&#xa0;mg/dL) and an increase in HDL-C (3.91 ± 5.07&#xa0;mg/dL) in the intervention group compared to the control group (<i>P</i> &lt; 0.05). These findings imply that TRF combined with a LOV diet enhances metabolic markers, liver health, and weight loss, thus potentially offering a practical dietary approach for managing MAFLD. Further long-term studies are necessary to validate these results and investigate their clinical applications.</p>

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Effects of time restricted feeding combined with Lacto Ovo vegetarian diet on metabolic associated fatty liver disease management: a randomized clinical trial

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年2月6日

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  • Mahshad Shafiee,
  • Amir Sadeghi,
  • Fateme Ghafouri-Taleghani,
  • Maryam Nilghaz,
  • Maryam Ghods,
  • Behnaz Narimani,
  • Azita Hekmatdoost,
  • Atoosa saidpour

摘要

Metabolic Associated Fatty Liver Disease (MAFLD) is becoming a major global health concern due to its links with obesity, insulin resistance, and cardiovascular risk. This randomized clinical trial assessed the effects of combining time-restricted feeding (TRF; 16/8) with a Lacto-Ovo-Vegetarian (LOV) diet on various factors in overweight and obese patients with MAFLD. Forty-six participants were randomly assigned to either the intervention group (TRF with LOV diet) or the control group, with 21 participants completing the 12-week study in each group. The intervention group showed significant reductions in weight (-8.07 ± 4.31 kg), BMI (-2.70 ± 1.32 kg/m2), waist circumference (-8.00 ± 4.06 cm), as well as ALT (-17.14 ± 14.33 U/L), GGT (-21.09 ± 24.06 U/L), Fatty Liver Index (-26.90 ± 15.81), insulin levels (-3.89 ± 4.69 mU/L), and TNF-α (-11.85 ± 12.52 pg/mL) compared to the control group (all P < 0.05). Lipid profiles also improved with a reduction in triglycerides (-46.85 ± 54.55 mg/dL) and an increase in HDL-C (3.91 ± 5.07 mg/dL) in the intervention group compared to the control group (P < 0.05). These findings imply that TRF combined with a LOV diet enhances metabolic markers, liver health, and weight loss, thus potentially offering a practical dietary approach for managing MAFLD. Further long-term studies are necessary to validate these results and investigate their clinical applications.