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<p>This study introduced a modified trabeculectomy method and compare its effectiveness and safety to prior studies. Twenty-seven glaucoma patients (32 eyes) underwent mitomycin C-augmented trabeculectomy with a unique scleral flap shape at Kaohsiung Veterans General Hospital. The IOP decreased significantly from baseline (28.80 ± 11.37&#xa0;mm Hg) to postoperative day 1, week 1, week 2, week 4, week 6, month 3, month 6, and year 1 (range, 14.10 ± 5.90 to 17.80 ± 5.14&#xa0;mm Hg; all <i>p</i> &lt; 0.05). The antiglaucoma medication use also decreased significantly from baseline (<i>n</i> = 4.72 ± 1.25) to 1 year after trabeculectomy (<i>n</i> = 0.75 ± 1.37) (<i>p</i> &lt; 0.001). No surgical failures or glaucoma reoperations occurred during follow-up. Early complications and interventions included bleb encapsulation (<i>n</i> = 3, 9.38%), bleb leaks (<i>n</i> = 3, 9.38%), and needling revision (<i>n</i> = 1, 3.13%). Late complications and interventions included bleb encapsulation (<i>n</i> = 2, 6.45%), needling (<i>n</i> = 5, 16.13%), and cataract extraction (<i>n</i> = 2, 6.45%). Our trabeculectomy method with a modified scleral flap shape has demonstrated comparable success rates and improved safety compared to existing techniques. However, as this is a retrospective study, further randomized controlled trials are needed to draw definitive conclusions regarding its superiority or comparability.</p>

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Safety and efficacy of a unique scleral flap in mitomycin C-augmented trabeculectomy over one year

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年2月27日

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  • En-Jie Shih,
  • Ying-Ying Chen

摘要

This study introduced a modified trabeculectomy method and compare its effectiveness and safety to prior studies. Twenty-seven glaucoma patients (32 eyes) underwent mitomycin C-augmented trabeculectomy with a unique scleral flap shape at Kaohsiung Veterans General Hospital. The IOP decreased significantly from baseline (28.80 ± 11.37 mm Hg) to postoperative day 1, week 1, week 2, week 4, week 6, month 3, month 6, and year 1 (range, 14.10 ± 5.90 to 17.80 ± 5.14 mm Hg; all p < 0.05). The antiglaucoma medication use also decreased significantly from baseline (n = 4.72 ± 1.25) to 1 year after trabeculectomy (n = 0.75 ± 1.37) (p < 0.001). No surgical failures or glaucoma reoperations occurred during follow-up. Early complications and interventions included bleb encapsulation (n = 3, 9.38%), bleb leaks (n = 3, 9.38%), and needling revision (n = 1, 3.13%). Late complications and interventions included bleb encapsulation (n = 2, 6.45%), needling (n = 5, 16.13%), and cataract extraction (n = 2, 6.45%). Our trabeculectomy method with a modified scleral flap shape has demonstrated comparable success rates and improved safety compared to existing techniques. However, as this is a retrospective study, further randomized controlled trials are needed to draw definitive conclusions regarding its superiority or comparability.