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<p>Nanopesticides have been recently introduced as novel pesticides to overcome the drawbacks of using traditional synthetic pesticides. The present study evaluated the acaricidal activity of Copper/Graphene oxide core-shell nanoparticles against two tick species, <i>Rhipicephalus rutilus</i> and <i>Rhipicephalus turanicus</i>. The Copper/Graphene oxide core-shell nanoparticles were synthetized through the solution plasma (SP) method under different conditions. The nanoparticles synthesized at 180&#xa0;W and 45&#xa0;min were highly toxic to <i>Rh. rutilus</i> and <i>Rh. turanicus</i>, with 50% lethal concentration (LC<sub>50</sub>) values of 248.1 and 195.7&#xa0;mg ml<sup>−1</sup>, respectively, followed by those which were synthesized at 120&#xa0;W/30 mins (LC<sub>50</sub> = 581.5 and 526.5&#xa0;mg ml<sup>−1</sup>), 120&#xa0;W/15 mins (LC<sub>50</sub> = 606.9 and 686.7&#xa0;mg ml<sup>−1</sup>), and 100/45 mins (LC<sub>50</sub> = 792.9 and 710.7&#xa0;mg ml<sup>−1</sup>), after 24&#xa0;h of application. The enzyme assays revealed that 180&#xa0;W/45 min treatment significantly inhibited the activity of acetylcholinesterase (115 ± 0.81 and 123 ± 0.33 U/ mg protein/min) and superoxide dismutase (290 ± 0.18 and 310 ± 0.92 U/ mg protein/min) in <i>Rh. rutilus</i> and <i>Rh. turanicus</i>, respectively, as compared with the negative control. The results also revealed a significantly increased catalase activity (895 ± 0.37 and 870 ± 0.31 U/ mg protein/min) in <i>Rh. rutilus</i> and <i>Rh. turanicus</i>, respectively. The above results indicated that Copper/Graphene oxide core-shell nanoparticles could be a promising alternatives for the management of ticks.</p>

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Effects of copper/graphene oxide core-shell nanoparticles on Rhipicephalus ticks and their detoxification enzymes

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年1月27日

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  • Haytham Senbill,
  • Amr Gangan,
  • Ahmed M. Saeed,
  • Mohammed E. Gad,
  • Jehan Zeb,
  • Alaa Fahmy

摘要

Nanopesticides have been recently introduced as novel pesticides to overcome the drawbacks of using traditional synthetic pesticides. The present study evaluated the acaricidal activity of Copper/Graphene oxide core-shell nanoparticles against two tick species, Rhipicephalus rutilus and Rhipicephalus turanicus. The Copper/Graphene oxide core-shell nanoparticles were synthetized through the solution plasma (SP) method under different conditions. The nanoparticles synthesized at 180 W and 45 min were highly toxic to Rh. rutilus and Rh. turanicus, with 50% lethal concentration (LC50) values of 248.1 and 195.7 mg ml−1, respectively, followed by those which were synthesized at 120 W/30 mins (LC50 = 581.5 and 526.5 mg ml−1), 120 W/15 mins (LC50 = 606.9 and 686.7 mg ml−1), and 100/45 mins (LC50 = 792.9 and 710.7 mg ml−1), after 24 h of application. The enzyme assays revealed that 180 W/45 min treatment significantly inhibited the activity of acetylcholinesterase (115 ± 0.81 and 123 ± 0.33 U/ mg protein/min) and superoxide dismutase (290 ± 0.18 and 310 ± 0.92 U/ mg protein/min) in Rh. rutilus and Rh. turanicus, respectively, as compared with the negative control. The results also revealed a significantly increased catalase activity (895 ± 0.37 and 870 ± 0.31 U/ mg protein/min) in Rh. rutilus and Rh. turanicus, respectively. The above results indicated that Copper/Graphene oxide core-shell nanoparticles could be a promising alternatives for the management of ticks.