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<p>This study aimed to compare the failure rates of two different sizes of plates and screws to stabilize critical-sized (7&#xa0;mm) femoral defects in male Sprague‒Dawley rats (aged 10 weeks). Femoral defects were stabilized with either a 4-hole plate (length 29&#xa0;mm, thickness 1&#xa0;mm, 10 rats, Group 1) and 4 cortical screws (diameter 2&#xa0;mm) or with a 6-hole plate (length 30&#xa0;mm, thickness 0.6&#xa0;mm, 9 rats, Group 2) and 4 cortical screws (diameter 1.5&#xa0;mm). A polymethylmethacrylate spacer was inserted into the defects to reproduce the first stage of the induced membrane technique. Radiographic evaluations, macroscopic and histologic assessments of the induced membranes were conducted at 1 week and 4 weeks. No implant failure occurred in Group 1 whereas in Group 2, 4/9 (44.4%) implant failures occurred during the follow-up (<i>p</i> = 0.03). On histomorphometry, cell density was higher in Group 1 (4996 ± 716 cells / mm²) than in Group 2 (3500 ± 728 cells/mm²) (<i>p</i> = 0.0195) but the membrane thickness in Group 1 (735 ± 44&#xa0;μm) was non-significantly lower than in Group 2 (979 ± 165&#xa0;μm) (<i>p</i> = 0.4). This study suggests that, in rat models of critical-sized femoral defects (7&#xa0;mm) to study the induced membrane technique, fixation plates with a thickness of 1&#xa0;mm and four screws (2&#xa0;mm in diameter) provide stable fixation without implant failure. In contrast, thinner plates (&lt; 1&#xa0;mm) combined with screws of smaller diameter (1.5&#xa0;mm) result in a high rate of implant failure.</p>

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Comparison of two plates and screw osteosynthesis configurations in a rat model of critical sized femoral defects to reduce implant related failures

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年1月22日

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  • Marc Saab,
  • Anne-Sophie Drucbert,
  • Nicolas Blanchemain,
  • Feng Chai

摘要

This study aimed to compare the failure rates of two different sizes of plates and screws to stabilize critical-sized (7 mm) femoral defects in male Sprague‒Dawley rats (aged 10 weeks). Femoral defects were stabilized with either a 4-hole plate (length 29 mm, thickness 1 mm, 10 rats, Group 1) and 4 cortical screws (diameter 2 mm) or with a 6-hole plate (length 30 mm, thickness 0.6 mm, 9 rats, Group 2) and 4 cortical screws (diameter 1.5 mm). A polymethylmethacrylate spacer was inserted into the defects to reproduce the first stage of the induced membrane technique. Radiographic evaluations, macroscopic and histologic assessments of the induced membranes were conducted at 1 week and 4 weeks. No implant failure occurred in Group 1 whereas in Group 2, 4/9 (44.4%) implant failures occurred during the follow-up (p = 0.03). On histomorphometry, cell density was higher in Group 1 (4996 ± 716 cells / mm²) than in Group 2 (3500 ± 728 cells/mm²) (p = 0.0195) but the membrane thickness in Group 1 (735 ± 44 μm) was non-significantly lower than in Group 2 (979 ± 165 μm) (p = 0.4). This study suggests that, in rat models of critical-sized femoral defects (7 mm) to study the induced membrane technique, fixation plates with a thickness of 1 mm and four screws (2 mm in diameter) provide stable fixation without implant failure. In contrast, thinner plates (< 1 mm) combined with screws of smaller diameter (1.5 mm) result in a high rate of implant failure.