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<p>The aim of this study was to compare the vaginal microbiome of women with different sexual behaviors and to examine characteristics associated with <i>Lactobacillus</i>-deprived community state type IV. In this prospective study performed in a community-based population in a city of approximately 150,000 inhabitants in Southeast region of Brazil, vaginal swabs were obtained of 109 participants, including women who only had sex with women (<i>n</i> = 54) and women who only had sex with man (<i>n</i> = 55). Sociodemographic data, sexual and intimated hygiene practices of the participants were also assessed. Vaginal microbiota was assessed by sequencing the hypervariable regions V3 and V4 of 16&#xa0;S ribosomal nucleic acid gene (Illumina 250 PE). Alpha diversity (Shannon index) was compared between the two groups by the Mann-Whitney test. Logistic regression analyses were performed to estimate odds ratios (OR) and 95% confidence intervals (CI) for the association between covariates with the <i>Lactobacillus</i>-deprived community state type IV. Results showed that overall distribution of vaginal CSTs did not differ between the two study groups (<i>P</i> = 0.19). However, alpha diversity was increased in women that only have sex with women (<i>P</i> = 0.0018). L<i>actobacillus</i>-deprived community state type IV was associated with lower income (OR: 4.15, 95% CI: 1.04–16.46) and use of sex toys (OR: 3.97, 95% CI: 1.09–14.45). In conclusion, nearly one-third of women that only have sex with women had a sub-optimal vaginal microbiome and show evidence of sex transmissibility of CST-IV associated organisms.</p>

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Characteristics associated with Lactobacillus-depleted vaginal microbiota in women with different sexual behavior

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月10日

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  • Mariana Alice de Oliveira Ignacio,
  • Camila Marconi,
  • Lucas Tadeu Bidinotto,
  • Eduardo Balsanelli,
  • Rafael Belleti,
  • Márcia Guimarães da Silva,
  • Marli Teresinha Cassamassimo Duarte

摘要

The aim of this study was to compare the vaginal microbiome of women with different sexual behaviors and to examine characteristics associated with Lactobacillus-deprived community state type IV. In this prospective study performed in a community-based population in a city of approximately 150,000 inhabitants in Southeast region of Brazil, vaginal swabs were obtained of 109 participants, including women who only had sex with women (n = 54) and women who only had sex with man (n = 55). Sociodemographic data, sexual and intimated hygiene practices of the participants were also assessed. Vaginal microbiota was assessed by sequencing the hypervariable regions V3 and V4 of 16 S ribosomal nucleic acid gene (Illumina 250 PE). Alpha diversity (Shannon index) was compared between the two groups by the Mann-Whitney test. Logistic regression analyses were performed to estimate odds ratios (OR) and 95% confidence intervals (CI) for the association between covariates with the Lactobacillus-deprived community state type IV. Results showed that overall distribution of vaginal CSTs did not differ between the two study groups (P = 0.19). However, alpha diversity was increased in women that only have sex with women (P = 0.0018). Lactobacillus-deprived community state type IV was associated with lower income (OR: 4.15, 95% CI: 1.04–16.46) and use of sex toys (OR: 3.97, 95% CI: 1.09–14.45). In conclusion, nearly one-third of women that only have sex with women had a sub-optimal vaginal microbiome and show evidence of sex transmissibility of CST-IV associated organisms.