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<p>We found that healthy mice harbor T cells with heritable low <i>Pten</i> expression and that monoallelic <i>Pten</i> loss in CD4 T cells causes a bias in their differentiation toward T follicular helper cells during acute viral infection. These results suggest that somatically induced mono- or biallelic loss of expression of signaling-related genes in T cells can impact the quality of population-level T cell responses—without conspicuous pathological sequelae such as autoimmune and inflammatory manifestations or lymphomagenesis.</p>

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Spontaneous somatic Pten loss contributes to functional heterogeneity of T cells

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月12日

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  • Allen Y. Chen,
  • Alexander Y. Rudensky

摘要

We found that healthy mice harbor T cells with heritable low Pten expression and that monoallelic Pten loss in CD4 T cells causes a bias in their differentiation toward T follicular helper cells during acute viral infection. These results suggest that somatically induced mono- or biallelic loss of expression of signaling-related genes in T cells can impact the quality of population-level T cell responses—without conspicuous pathological sequelae such as autoimmune and inflammatory manifestations or lymphomagenesis.