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Introduction <p>Most resting-state functional connectivity (rs-FC) research does not consider the participant’s subjective state during magnetic resonance imaging (MRI). Heightened anxiety before an MRI (“pre-scanning state anxiety”) may influence rs-FC and complicate interpretation of individual differences, particularly in underrepresented groups whose scanning experiences may differ from typical research samples.</p> Methods <p>We assessed associations between pre-scanning state anxiety and rs-FC within and between the default mode network (DMN) and salience network in a trait-anxious community sample of Latina girls (8–13 years) and a companion sample of treatment-seeking and healthy youth (8–18 years) of predominantly non-Latinx background. A constrained network-based statistical approach calculated the average of un-thresholded correlation coefficients from edge-level partial Spearman correlations to produce network-level measures (7 cortical + 1 subcortical). This approach is “constrained” in that analyses operate at the spatial scale of functional networks, rather than individual edges, to increase statistical power. Statistics were compared against a permutation-based null distribution to assess significance (Bonferroni corrected <i>p</i> &lt; 0.00139).</p> Results <p>Reduced rs-FC within the DMN (<i>r</i> = − 0.32, <i>p</i> &lt; 0.00139) was associated with pre-scanning state anxiety in the community sample, but did not replicate in our companion sample.</p> Discussion <p>Pre-scanning state anxiety is associated with rs-FC within the DMN, but only among a trait-anxious community sample. Individual differences in MRI scanning experiences may be associated with rs-FC, but sample characteristics and replication should be considered.</p>

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Children’s state anxiety before MRI scanning and resting state functional connectivity in large scale brain networks

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月16日

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  • Purnima Qamar,
  • Dana E. Díaz,
  • Brenda E. Benson,
  • Daniel S. Pine,
  • Peter A. Kirk,
  • Kalina J. Michalska

摘要

Introduction

Most resting-state functional connectivity (rs-FC) research does not consider the participant’s subjective state during magnetic resonance imaging (MRI). Heightened anxiety before an MRI (“pre-scanning state anxiety”) may influence rs-FC and complicate interpretation of individual differences, particularly in underrepresented groups whose scanning experiences may differ from typical research samples.

Methods

We assessed associations between pre-scanning state anxiety and rs-FC within and between the default mode network (DMN) and salience network in a trait-anxious community sample of Latina girls (8–13 years) and a companion sample of treatment-seeking and healthy youth (8–18 years) of predominantly non-Latinx background. A constrained network-based statistical approach calculated the average of un-thresholded correlation coefficients from edge-level partial Spearman correlations to produce network-level measures (7 cortical + 1 subcortical). This approach is “constrained” in that analyses operate at the spatial scale of functional networks, rather than individual edges, to increase statistical power. Statistics were compared against a permutation-based null distribution to assess significance (Bonferroni corrected p < 0.00139).

Results

Reduced rs-FC within the DMN (r = − 0.32, p < 0.00139) was associated with pre-scanning state anxiety in the community sample, but did not replicate in our companion sample.

Discussion

Pre-scanning state anxiety is associated with rs-FC within the DMN, but only among a trait-anxious community sample. Individual differences in MRI scanning experiences may be associated with rs-FC, but sample characteristics and replication should be considered.