<p>Infantile colic is an important problem encountered during the first months of life. This study investigated the effect of infantile colic training provided to parents on the severity of neonatal infantile colic and the duration of crying. The research used a one-group pretest–posttest design. The study was conducted among the mothers and fathers of newborns who attended a Family Health Center between May and October 2024 and were diagnosed with infantile colic. A power analysis was conducted, and the sample consisted of 60 parents. Parents received infantile colic training in a single session, and its effectiveness was evaluated at two different times. Data were obtained via a questionnaire that included a sociodemographic form and the Infantile Colic Scale. The crying times of the newborns were recorded based on the information provided by the parents. Statistically significant differences in the Infantile Colic Scale scores were not found in mothers after the training; however, significant differences were observed in the first post-education assessment of fathers and between the parents’ first and second assessments. The mean duration of infant crying after the training was found to have a high effect size. After the training, it was found that the severity of newborn infantile colic and the duration of crying decreased. This training is an effective intervention for neonatal infantile colic.</p>