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<p>Hepatocellular carcinoma (HCC) is one of the commonly lethal malignancies worldwide and represents a major global health-care challenge. We have previously demonstrated that plumbagin (PLB) could inhibit the development of tumor in liver, but the mechanism is still not fully clear. Here we identified a transcription repressor-homeobox containing 1 (HMBOX1) as a regulator in the development of HCC.Knockdown of HMBOX1 resulted into expansive of tumor cells, while overexpression led to growth inhibition. Mechanistically, PLB promoted HMBOX1 expression, leading to inactivation of PI3K/Akt-mTOR of liver cancer cells. Moreover, PLB also inhibited tumor formation in a xenograft transplantation model via PI3K/Akt/mTOR signaling. Collectively, our results suggested that HMBOX1 played a key role in PLB-induced inhibition of HCC growth through PI3K/Akt/mTOR signaling pathway.</p>

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HMBOX1 plays a critical role in plumbagin-induced growth inhibition of hepatocellular carcinoma cells

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月24日

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  • Yanfei Wei,
  • Tao Cheng,
  • Hong Liu,
  • Yuanzheng Ma,
  • Huan Liu,
  • Yuanqin Du,
  • Shuye Deng

摘要

Hepatocellular carcinoma (HCC) is one of the commonly lethal malignancies worldwide and represents a major global health-care challenge. We have previously demonstrated that plumbagin (PLB) could inhibit the development of tumor in liver, but the mechanism is still not fully clear. Here we identified a transcription repressor-homeobox containing 1 (HMBOX1) as a regulator in the development of HCC.Knockdown of HMBOX1 resulted into expansive of tumor cells, while overexpression led to growth inhibition. Mechanistically, PLB promoted HMBOX1 expression, leading to inactivation of PI3K/Akt-mTOR of liver cancer cells. Moreover, PLB also inhibited tumor formation in a xenograft transplantation model via PI3K/Akt/mTOR signaling. Collectively, our results suggested that HMBOX1 played a key role in PLB-induced inhibition of HCC growth through PI3K/Akt/mTOR signaling pathway.