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<p>Somatic neurological complications are an underexplored component of post-acute sequelae of SARS-CoV-2 infection. We evaluated long-term somatic neurological symptoms, examination findings, and suspected diagnoses among adults hospitalized for COVID-19. A total of 708 survivors were assessed 6–11 months after discharge using a structured three-step neurological evaluation based on the World Health Organization <i>Protocol for Epidemiologic Studies of Neurologic Disorders</i>: an adapted symptom questionnaire, a brief standardized neurological examination, and a full neurological consult. Muscle weakness, gait impairment, and paresthesias remained the most frequent symptoms at follow-up. Longer hospital stay predicted all three symptoms, and diabetes was associated with both gait impairment and paresthesias. Common examination findings included monoparesis, hemiparesis, and gradient-pattern sensory loss. Clinically suspected diagnoses included neuromuscular disease in 26%, cerebrovascular disease in 10%, and epilepsy in only 2.7% of cases. Logistic regression linked neuromuscular disease to paresthesias and tandem-walk failure, cerebrovascular disease to facial paralysis, and epilepsy to loss-of-contact episodes. A simplified screening model derived through best-subsets selection identified five informative items from the WHO protocol: paresthesias, facial paralysis, tandem walk, index–nose test, and loss-of-contact episodes. These findings indicate that somatic neurological abnormalities remain frequent months after severe COVID-19 and that a brief bedside subset may support efficient post-COVID neurological triage.</p>

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Neurological symptoms and physical exam findings 6–11 months post-COVID-19: a cohort study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月2日

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  • Bruno Fukelmann Guedes,
  • Ana Paula Ritto,
  • Andre Macedo Serafim Silva,
  • Antonio Edvan Camelo Filho,
  • Cristiane de Araújo Martins Moreno,
  • Marcos Vinícius Oliveira Marques,
  • Mariana Ribeiro Marcondes da Silveira,
  • Raphael de Luca eTuma,
  • José Pedro Soares Baima,
  • Sâmia Yasin Wayhs,
  • Rodrigo de Holanda Mendonça,
  • Cristiana Borges Pereira,
  • Bruno Diógenes Iepsen,
  • Barbara Leite Costa,
  • Emanuelle Roberta da Silva Aquino,
  • Julia Chartouni Rodrigues,
  • Geraldo Busatto Filho,
  • Edmar Zanoteli,
  • Suely Kazue Nagahashi Marie,
  • Ricardo Nitrini,
  • Luiz Henrique Martins Castro

摘要

Somatic neurological complications are an underexplored component of post-acute sequelae of SARS-CoV-2 infection. We evaluated long-term somatic neurological symptoms, examination findings, and suspected diagnoses among adults hospitalized for COVID-19. A total of 708 survivors were assessed 6–11 months after discharge using a structured three-step neurological evaluation based on the World Health Organization Protocol for Epidemiologic Studies of Neurologic Disorders: an adapted symptom questionnaire, a brief standardized neurological examination, and a full neurological consult. Muscle weakness, gait impairment, and paresthesias remained the most frequent symptoms at follow-up. Longer hospital stay predicted all three symptoms, and diabetes was associated with both gait impairment and paresthesias. Common examination findings included monoparesis, hemiparesis, and gradient-pattern sensory loss. Clinically suspected diagnoses included neuromuscular disease in 26%, cerebrovascular disease in 10%, and epilepsy in only 2.7% of cases. Logistic regression linked neuromuscular disease to paresthesias and tandem-walk failure, cerebrovascular disease to facial paralysis, and epilepsy to loss-of-contact episodes. A simplified screening model derived through best-subsets selection identified five informative items from the WHO protocol: paresthesias, facial paralysis, tandem walk, index–nose test, and loss-of-contact episodes. These findings indicate that somatic neurological abnormalities remain frequent months after severe COVID-19 and that a brief bedside subset may support efficient post-COVID neurological triage.