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<p>This study developed a simple and label-free fluorescent probe for deferiprone quantification in exhaled breath condensate (EBC) samples. For that, UiO-66, synthesized in a one-step process with the solvothermal method, along with ferric ions, provided a selective system for deferiprone detection. Deferiprone formed a complex with ferric ions, and the resulting complex quenched the fluorescence intensity of UiO-66 through an inner filter effect process. The probe demonstrated good sensitivity, with a detection limit of 0.005 mg.L<sup>− 1</sup> and a linear range of 0.016-1.0 mg.L<sup>− 1</sup>, and performed reliably in the analysis of deferiprone in EBC samples of the patients.</p>

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A label-free fluorescent probe for deferiprone quantification in exhaled breath condensate utilizing UiO-66 MOF/ferric ions system

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月24日

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  • Nima Sheikh Abdollahzadeh Mamaghani,
  • Zahra Karimzadeh,
  • Maryam Khoubnasabjafari,
  • Vahid Jouyban-Gharamaleki,
  • Elaheh Rahimpour,
  • Abolghasem Jouyban

摘要

This study developed a simple and label-free fluorescent probe for deferiprone quantification in exhaled breath condensate (EBC) samples. For that, UiO-66, synthesized in a one-step process with the solvothermal method, along with ferric ions, provided a selective system for deferiprone detection. Deferiprone formed a complex with ferric ions, and the resulting complex quenched the fluorescence intensity of UiO-66 through an inner filter effect process. The probe demonstrated good sensitivity, with a detection limit of 0.005 mg.L− 1 and a linear range of 0.016-1.0 mg.L− 1, and performed reliably in the analysis of deferiprone in EBC samples of the patients.