Scholarlink

<p>Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent liver disease worldwide, particularly among individuals with overweight and obesity. Non-pharmacological strategies such as time-restricted feeding (TRF) and exercise training can effectively mitigate obesity and metabolic disorders associated with MASLD. However, the specific effects of TRF combined with aerobic training (AT), resistance training (RT), or combined training (CT) on weight loss and MASLD remain unclear. This study investigated the effects of 12&#xa0;h-TRF and exercise training (AT, RT, and CT), applied alone or in combination with TRF, for 10 weeks in diet-induced obese male Swiss mice. Individually, TRF and all exercise protocols reduced weight gain and adiposity, improved glycemic homeostasis, and decreased hepatic fat accumulation. Combining TRF with exercise resulted in more pronounced improvements, suggesting complementary mechanisms. Among the interventions, TRF + AT was the most effective in reducing body weight, fat mass, and hepatic saturated fatty acid accumulation. TRF + CT induced similar effects but with a less marked reduction in hepatic steatosis. Moreover, TRF + AT downregulated lipogenic and inflammatory genes while upregulating genes related to hepatic fatty acid oxidation. TRF + RT was particularly effective in improving glucose homeostasis and insulin sensitivity. In conclusion, combining TRF with AT, RT, or CT significantly improved metabolic and hepatic parameters compared to TRF or training alone in obese mice. These findings highlight the synergistic potential of TRF and exercise and emphasize their specific outcomes, providing new perspectives for personalized interventions against obesity and MASLD.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Integration of 12-h time-restricted feeding with exercise training potentiates weight loss and attenuates MASLD in diet-induced obese mice

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月10日

查看全文
  • Guilherme Correia Ferri Antonio,
  • Ana Paula Azevêdo Macêdo,
  • Gabriel Calheiros Antunes,
  • Robson Damasceno de Lima,
  • Thaiane da Silva Rios,
  • Beatriz de Souza Pitoli,
  • Guilherme Domingos Brisque,
  • Larissa Moreira Dias,
  • Adelino Sanchez Ramos da Silva,
  • Dennys Esper Cintra,
  • Rania A. Mekary,
  • Eduardo Rochete Ropelle,
  • Amandine Chaix,
  • José Rodrigo Pauli

摘要

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent liver disease worldwide, particularly among individuals with overweight and obesity. Non-pharmacological strategies such as time-restricted feeding (TRF) and exercise training can effectively mitigate obesity and metabolic disorders associated with MASLD. However, the specific effects of TRF combined with aerobic training (AT), resistance training (RT), or combined training (CT) on weight loss and MASLD remain unclear. This study investigated the effects of 12 h-TRF and exercise training (AT, RT, and CT), applied alone or in combination with TRF, for 10 weeks in diet-induced obese male Swiss mice. Individually, TRF and all exercise protocols reduced weight gain and adiposity, improved glycemic homeostasis, and decreased hepatic fat accumulation. Combining TRF with exercise resulted in more pronounced improvements, suggesting complementary mechanisms. Among the interventions, TRF + AT was the most effective in reducing body weight, fat mass, and hepatic saturated fatty acid accumulation. TRF + CT induced similar effects but with a less marked reduction in hepatic steatosis. Moreover, TRF + AT downregulated lipogenic and inflammatory genes while upregulating genes related to hepatic fatty acid oxidation. TRF + RT was particularly effective in improving glucose homeostasis and insulin sensitivity. In conclusion, combining TRF with AT, RT, or CT significantly improved metabolic and hepatic parameters compared to TRF or training alone in obese mice. These findings highlight the synergistic potential of TRF and exercise and emphasize their specific outcomes, providing new perspectives for personalized interventions against obesity and MASLD.