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<p>We aimed to investigate prognostic determinants of extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). We analyzed 11,730 patients captured in the National cancer registry. Kaplan–Meier estimates compared survival by sex, age, and SEER stage, while multivariable Cox models identified mortality determinants. Women represented 54.6% of cases and had better survival than men. Age distribution peaked in the fifth–sixth decades. Survival declined with older age and advanced SEER stage. In multivariable models, male sex (hazard ratio [HR] 2.00, 95% confidence interval [CI] 1.48–2.70), advanced age (HR 33.92, 95% CI 18.23–63.10 for ≥ 80&#xa0;years), and metastatic disease (HR 2.77, 95% CI 2.03–3.78), diabetes, cardiovascular, and cerebrovascular disease were associated with higher mortality. Conversely, higher household income (HR 0.63, 95% CI 0.45–0.88), physical activity (HR 0.60, 95% CI 0.42–0.86), and higher body mass index (HR 0.95, 95% CI 0.91–0.99) were associated with reduced mortality. Subgroup analyses showed consistently worse outcomes for men across age strata. Comorbidity effects were most pronounced at ages 60–79. Income, physical activity, smoking, and BMI have age-specific survival benefits. In conclusion, prognosis in MALT lymphoma is strongly influenced by sex, age, stage, comorbidities, and lifestyle.</p>

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Prognostic outcome of extranodal marginal zone B-cell lymphoma: a nationwide cohort

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月16日

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  • Su Youn Nam,
  • Junwoo Jo

摘要

We aimed to investigate prognostic determinants of extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). We analyzed 11,730 patients captured in the National cancer registry. Kaplan–Meier estimates compared survival by sex, age, and SEER stage, while multivariable Cox models identified mortality determinants. Women represented 54.6% of cases and had better survival than men. Age distribution peaked in the fifth–sixth decades. Survival declined with older age and advanced SEER stage. In multivariable models, male sex (hazard ratio [HR] 2.00, 95% confidence interval [CI] 1.48–2.70), advanced age (HR 33.92, 95% CI 18.23–63.10 for ≥ 80 years), and metastatic disease (HR 2.77, 95% CI 2.03–3.78), diabetes, cardiovascular, and cerebrovascular disease were associated with higher mortality. Conversely, higher household income (HR 0.63, 95% CI 0.45–0.88), physical activity (HR 0.60, 95% CI 0.42–0.86), and higher body mass index (HR 0.95, 95% CI 0.91–0.99) were associated with reduced mortality. Subgroup analyses showed consistently worse outcomes for men across age strata. Comorbidity effects were most pronounced at ages 60–79. Income, physical activity, smoking, and BMI have age-specific survival benefits. In conclusion, prognosis in MALT lymphoma is strongly influenced by sex, age, stage, comorbidities, and lifestyle.