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<p>Biofilm-associated infections due to recalcitrant bacterial pathogens pose a major challenge to global public health. <i>Acinetobacter baumannii</i> (<i>A. baumannii</i>) a multidrug-resistant bacterial pathogen, relies on biofilm formation and quorum sensing (QS) for sustained virulence and survival in the host. Here, we evaluated the anti-biofilm and anti-virulence potential of <i>Myroxylon balsamum</i> essential oil (<i>M. balsamum</i> EO) against <i>A. baumannii</i> (MCC-AB-07). <i>M. balsamum</i> EO disrupted biofilm formation, inhibited swarming motility, and increased bacterial susceptibility to oxidative stress. Our RT-qPCR investigations confirmed downregulation of key biofilm and QS genes. Additionally, <i>M. balsamum</i> EO resulted in improved survival of <i>Caenorhabditis elegans</i> following infection. Our findings indicate promising anti-biofilm and anti-virulence properties of <i>M. balsamum</i> EO, warranting elaborate investigations to explore its therapeutic applications and possible synergistic and complementary effects in conjunction with antibiotics.</p>

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Attenuation of biofilm-encoding genes and virulence attributes in clinical isolates of Acinetobacter baumannii by essential oil derived from Myroxylon balsamum

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月22日

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  • Naji Naseef Pathoor,
  • Pitchaipillai Sankar Ganesh,
  • Rajesh Kanna Gopal,
  • Abdul R. Anshad,
  • Esaki M. Shankar,
  • Vanitha Mariappan,
  • Siddhardha Busi,
  • Simi Asma Salim,
  • Nachammai Kathiresan,
  • Langeswaran Kulanthaivel,
  • Ramatchandirane Mahesh,
  • Parthiban Rudrapathy,
  • Esaki Muthu Ponmalar,
  • Kitlangki Suchiang

摘要

Biofilm-associated infections due to recalcitrant bacterial pathogens pose a major challenge to global public health. Acinetobacter baumannii (A. baumannii) a multidrug-resistant bacterial pathogen, relies on biofilm formation and quorum sensing (QS) for sustained virulence and survival in the host. Here, we evaluated the anti-biofilm and anti-virulence potential of Myroxylon balsamum essential oil (M. balsamum EO) against A. baumannii (MCC-AB-07). M. balsamum EO disrupted biofilm formation, inhibited swarming motility, and increased bacterial susceptibility to oxidative stress. Our RT-qPCR investigations confirmed downregulation of key biofilm and QS genes. Additionally, M. balsamum EO resulted in improved survival of Caenorhabditis elegans following infection. Our findings indicate promising anti-biofilm and anti-virulence properties of M. balsamum EO, warranting elaborate investigations to explore its therapeutic applications and possible synergistic and complementary effects in conjunction with antibiotics.