<p>The accurate identification of peripheral nerves using ultrasound is essential for the safe and effective application of image-guided interventions in pain management. The femoral nerve (FN) and saphenous nerve (SN) are common targets for peripheral nerve invasive techniques, yet their depth and anatomical variability can impact procedural success. The objective was to describe the ultrasound anatomy of the FN and SN in healthy individuals and analyze how anthropometric variables predict its location. Design: A cross-sectional study was conducted in 30 healthy participants. Ultrasound measurements included subcutaneous tissue thickness, nerve depth, and cross-sectional area of the FN and SN. Anthropometric data such as BMI, limb length, and circumference measurements were also recorded. Pearson correlations and hierarchical regression models were used to identify predictors of nerve location. Results: No significant side-to-side differences were found for any variable (p &gt; 0.05). Subcutaneous tissue thickness and limb circumference showed strong correlations with nerve depth. The final hierarchical regression model explained 67.0% of the variance in skin-to-FN distance and 82.3% for skin-to-SN distance. Subcutaneous tissue at the inguinal region and mid-thigh, as well as lower limb length and mid-thigh circumference, were significant predictors for FN depth. For the SN, subcutaneous thickness at mid-thigh, mid-thigh circumference, and inguinal subcutaneous tissue were the most relevant predictors. Conclusion: Anthropometric variables, especially subcutaneous tissue thickness and limb circumferences, are reliable predictors of FN and SN depth in healthy subjects. These findings support the use of simple anatomical measures to improve planning and safety in ultrasound-guided procedures.</p>