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<p>Falls are a leading cause of morbidity and mortality in older adults, with head injuries posing significant risk. Fall-risk-increasing drugs (FRIDs) contribute to falls, but their relationship with head injuries remains unclear. This observational, cross-sectional study aimed to examine the prevalence of fall-risk-increasing drug (FRID) use and the association between specific FRID classes and fall-related head injuries in older adults. We analyzed medical records of 1,085 adults aged ≥ 60 years who presented with falls at a tertiary hospital in Northern Thailand between January and December 2023. Of these, 47.1% sustained head injuries and 71.7% used FRIDs. The most frequently used FRIDs were opioids (33.0%), anticholinergics (26.8%), and antihistamines (22.5%). Multivariable logistic regression revealed that Z-drugs (aOR = 3.09, 95% CI: 1.15–8.26, <i>p</i> = 0.025), antipsychotics (aOR = 2.75, 95% CI: 1.40–5.39, <i>p</i> = 0.003), and benzodiazepines (aOR = 1.76, 95% CI: 1.16–2.66, <i>p</i> = 0.008) were positively associated with head injuries. Conversely, anticholinergics (aOR = 0.54, 95% CI: 0.40–0.72, <i>p</i> &lt; 0.001) and opioids (aOR = 0.39, 95% CI: 0.30–0.51, <i>p</i> &lt; 0.001) showed negative associations. These findings emphasize the need for careful medication management to prevent serious fall-related outcomes in geriatric populations.</p>

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Prevalence and association of fall-risk-increasing drugs (FRIDs) with fall-related head and non-head injuries in older adults: a retrospective database study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月26日

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  • Waranun Chimyaem,
  • Yanee Choksomngam,
  • Nida Buawangpong,
  • Nalinee Yingchankul,
  • Kanokporn Pinyopornpanish

摘要

Falls are a leading cause of morbidity and mortality in older adults, with head injuries posing significant risk. Fall-risk-increasing drugs (FRIDs) contribute to falls, but their relationship with head injuries remains unclear. This observational, cross-sectional study aimed to examine the prevalence of fall-risk-increasing drug (FRID) use and the association between specific FRID classes and fall-related head injuries in older adults. We analyzed medical records of 1,085 adults aged ≥ 60 years who presented with falls at a tertiary hospital in Northern Thailand between January and December 2023. Of these, 47.1% sustained head injuries and 71.7% used FRIDs. The most frequently used FRIDs were opioids (33.0%), anticholinergics (26.8%), and antihistamines (22.5%). Multivariable logistic regression revealed that Z-drugs (aOR = 3.09, 95% CI: 1.15–8.26, p = 0.025), antipsychotics (aOR = 2.75, 95% CI: 1.40–5.39, p = 0.003), and benzodiazepines (aOR = 1.76, 95% CI: 1.16–2.66, p = 0.008) were positively associated with head injuries. Conversely, anticholinergics (aOR = 0.54, 95% CI: 0.40–0.72, p < 0.001) and opioids (aOR = 0.39, 95% CI: 0.30–0.51, p < 0.001) showed negative associations. These findings emphasize the need for careful medication management to prevent serious fall-related outcomes in geriatric populations.