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<p>Refractory wounds impose a significant burden on patients and society. Although diagnostic ultrasound combined with microbubble contrast agents (USMB) improves microcirculation, its role in wound healing-particularly the underlying mechanisms-remains unclear. Here, we established a rat model of acute wounds and demonstrated that USMB therapy accelerated re-epithelialization and collagen deposition, accompanied by increased CD31 and VEGF expression, reduced IL-1β and TNF-α, and elevated TGF-β. By analyzing miRNA profiles, we revealed that USMB treatment was associated with the downregulation of miR-26b-5p. This molecule may target Gsk3β, thereby affecting the PI3K/Akt/GSK-3β signaling pathway and participating in USMB-mediated wound repair. These findings clarify the potential of USMB in wound therapy.</p>

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Diagnostic ultrasound-microbubble therapy promotes wound healing through miR-26b-5p-mediated GSK3β suppression

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月4日

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  • Nan Huang,
  • Na Sun,
  • Huabin Yang,
  • Rui Wang,
  • Linling Li,
  • Jie Tao,
  • Qian Feng,
  • Zhong Chen

摘要

Refractory wounds impose a significant burden on patients and society. Although diagnostic ultrasound combined with microbubble contrast agents (USMB) improves microcirculation, its role in wound healing-particularly the underlying mechanisms-remains unclear. Here, we established a rat model of acute wounds and demonstrated that USMB therapy accelerated re-epithelialization and collagen deposition, accompanied by increased CD31 and VEGF expression, reduced IL-1β and TNF-α, and elevated TGF-β. By analyzing miRNA profiles, we revealed that USMB treatment was associated with the downregulation of miR-26b-5p. This molecule may target Gsk3β, thereby affecting the PI3K/Akt/GSK-3β signaling pathway and participating in USMB-mediated wound repair. These findings clarify the potential of USMB in wound therapy.