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<p>Recurrent osteomyelitis remains a formidable challenge, with failure rates exceeding 25%. This study establishes a reproducible rabbit femoral model to systematically map the spatiotemporal pathogenesis of Staphylococcus aureus-induced osteomyelitis. Through longitudinal micro-CT and histo-morphometric analysis, we delineated a progressive pathological continuum: Acute trabecular destruction at 2 weeks advanced to subacute cortical devascularization by 4 weeks, culminating in chronic epiphyseal compromise with articular surface collapse at 6 weeks. A critical finding was the region-specific vulnerability to infection, with the diaphysis and condyle exhibiting distinct patterns of destruction. These quantitative pathoanatomical data directly inform a novel design paradigm for future bone regeneration strategies. We propose that effective therapeutic scaffolds must adopt a functionally graded approach, addressing the unique mechanical and biological requirements of each compromised region — specifically, tailored porosity gradients and architectural features for the diaphysis versus the condyle — rather than employing a uniform design. This work converts descriptive pathological progression into a set of predictive engineering criteria, providing a foundational platform for the future development of targeted infected-bone reconstruction.</p>

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Spatiotemporal mapping of osteomyelitis pathogenesis guides the design of functionally graded bone regeneration scaffolds

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月22日

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  • Chenxin Wang,
  • Li Chen,
  • Yijing Stehle,
  • Mingyue Lin,
  • Rui Zhang,
  • Huanshuo Zhang,
  • Jiehui Yang,
  • Denglang Hu,
  • Mao Yang,
  • Min Huang,
  • Yubao Li,
  • Qin Zou

摘要

Recurrent osteomyelitis remains a formidable challenge, with failure rates exceeding 25%. This study establishes a reproducible rabbit femoral model to systematically map the spatiotemporal pathogenesis of Staphylococcus aureus-induced osteomyelitis. Through longitudinal micro-CT and histo-morphometric analysis, we delineated a progressive pathological continuum: Acute trabecular destruction at 2 weeks advanced to subacute cortical devascularization by 4 weeks, culminating in chronic epiphyseal compromise with articular surface collapse at 6 weeks. A critical finding was the region-specific vulnerability to infection, with the diaphysis and condyle exhibiting distinct patterns of destruction. These quantitative pathoanatomical data directly inform a novel design paradigm for future bone regeneration strategies. We propose that effective therapeutic scaffolds must adopt a functionally graded approach, addressing the unique mechanical and biological requirements of each compromised region — specifically, tailored porosity gradients and architectural features for the diaphysis versus the condyle — rather than employing a uniform design. This work converts descriptive pathological progression into a set of predictive engineering criteria, providing a foundational platform for the future development of targeted infected-bone reconstruction.