Scholarlink

<p>Preterm birth is associated with various health consequences. However, the long-term impact on bone health remains unclear. This study compares bone health from infancy into mid-adulthood between preterm and term-born individuals and explores potential association with fracture status. Data from the Zurich Longitudinal Studies were analyzed, including preterm and term-born individuals (enrolled 1974–1979). Bone health was measured longitudinally using the Bone Health Index (BHI) from hand X-rays analyzed by BoneXpert. Fracture history was obtained through parental interviews and self-reports. Generalized estimating equation models evaluated BHI over age, adjusting for age, sex, preterm and fracture status. 1582 X-rays from 95 term and 120 preterm individuals, across 17 time points (3&#xa0;months to 47&#xa0;years of age) were analyzed. Preterm individuals (median gestational age 34.1&#xa0;weeks, IQR ± 3.1) had significantly lower BHI than term-born peers (<i>p</i> = <i>0.016</i>), with a deficit persisting until 4.5&#xa0;years of age. Thereafter no difference was found. No significant association between BHI and fracture status in mid-adulthood was found <i>(p</i> = <i>0.43).</i> In this cohort of predominantly moderate to late preterm infants, catch-up in bone health was achieved in early childhood and maintained into mid-adulthood. How bone health and fracture status evolve in later life remains unclear and requires a lifespan perspective on preterm birth.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Longitudinal course of bone health from infancy to mid-adulthood in preterm and term-born individuals

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月26日

查看全文
  • Julie Brecher,
  • Aziz Chaouch,
  • Daniel Konrad,
  • Dominique A. Eichelberger,
  • Beatrice Latal,
  • Oskar G. Jenni,
  • Nina Lenherr-Taube,
  • Flavia M. Wehrle

摘要

Preterm birth is associated with various health consequences. However, the long-term impact on bone health remains unclear. This study compares bone health from infancy into mid-adulthood between preterm and term-born individuals and explores potential association with fracture status. Data from the Zurich Longitudinal Studies were analyzed, including preterm and term-born individuals (enrolled 1974–1979). Bone health was measured longitudinally using the Bone Health Index (BHI) from hand X-rays analyzed by BoneXpert. Fracture history was obtained through parental interviews and self-reports. Generalized estimating equation models evaluated BHI over age, adjusting for age, sex, preterm and fracture status. 1582 X-rays from 95 term and 120 preterm individuals, across 17 time points (3 months to 47 years of age) were analyzed. Preterm individuals (median gestational age 34.1 weeks, IQR ± 3.1) had significantly lower BHI than term-born peers (p = 0.016), with a deficit persisting until 4.5 years of age. Thereafter no difference was found. No significant association between BHI and fracture status in mid-adulthood was found (p = 0.43). In this cohort of predominantly moderate to late preterm infants, catch-up in bone health was achieved in early childhood and maintained into mid-adulthood. How bone health and fracture status evolve in later life remains unclear and requires a lifespan perspective on preterm birth.