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<p>The relationship between exercise tolerance and body composition in chronic thromboembolic pulmonary hypertension (CTEPH) is not well-understood. This study assessed body composition and its link to the 6-min walk distance (6MWD) in 181 patients with CTEPH, analyzing 257 health status assessments from 2018 to 2021. Patients underwent right heart catheterization, bioelectrical impedance analysis for body composition, and 6MWD evaluations. The mean pulmonary arterial pressure and 6MWD were 20&#xa0;mmHg (interquartile range [IQR]:16–25) and 414&#xa0;m (IQR:354–490), respectively. The skeletal muscle index (SMI) and phase angle (PhA) were 6.4&#xa0;kg/m<sup>2</sup> (IQR: 5.7–7.2) and 4.4° (IQR: 4.0–5.1), respectively. The 6MWD was associated with age (<i>β</i> = –0.19; 95% confidence interval [CI]: –0.32, –0.07; <i>p</i> = 0.003), male sex (<i>β</i> = 0.22; 95% CI: 0.10, 0.34; <i>p</i> &lt; 0.001), mean pulmonary arterial pressure (<i>β</i> = –0.32; 95% CI: –0.42, –0.21; <i>p</i> &lt; 0.001), and PhA (<i>β</i> = 0.21; 95% CI: 0.06, 0.36; <i>p</i> = 0.005). However, SMI did not show any association with 6MWD. The study suggests PhA as a potential simple marker for exercise tolerance in patients with CTEPH, pending further validation for therapeutic targeting.</p>

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Association of bioelectrical impedance phase angle with exercise tolerance in patients with chronic thromboembolic pulmonary hypertension

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月8日

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  • Daiki Shimizu,
  • Ayumi Goda,
  • Syoichi Tashiro,
  • Kazuki Tobita,
  • Takumi Inami,
  • Hanako Kikuchi,
  • Kaori Takeuchi,
  • Sayaka Funabashi,
  • Kazutaka Shimizu,
  • Shin Yamada,
  • Kyoko Soejima,
  • Takashi Kohno

摘要

The relationship between exercise tolerance and body composition in chronic thromboembolic pulmonary hypertension (CTEPH) is not well-understood. This study assessed body composition and its link to the 6-min walk distance (6MWD) in 181 patients with CTEPH, analyzing 257 health status assessments from 2018 to 2021. Patients underwent right heart catheterization, bioelectrical impedance analysis for body composition, and 6MWD evaluations. The mean pulmonary arterial pressure and 6MWD were 20 mmHg (interquartile range [IQR]:16–25) and 414 m (IQR:354–490), respectively. The skeletal muscle index (SMI) and phase angle (PhA) were 6.4 kg/m2 (IQR: 5.7–7.2) and 4.4° (IQR: 4.0–5.1), respectively. The 6MWD was associated with age (β = –0.19; 95% confidence interval [CI]: –0.32, –0.07; p = 0.003), male sex (β = 0.22; 95% CI: 0.10, 0.34; p < 0.001), mean pulmonary arterial pressure (β = –0.32; 95% CI: –0.42, –0.21; p < 0.001), and PhA (β = 0.21; 95% CI: 0.06, 0.36; p = 0.005). However, SMI did not show any association with 6MWD. The study suggests PhA as a potential simple marker for exercise tolerance in patients with CTEPH, pending further validation for therapeutic targeting.