Scholarlink

<p>Genistein (GEN) exhibits diverse biological activities. This study is conducted to explore the effect of GEN on metabolic dysfunction-associated steatotic liver disease (MASLD) mice. MASLD was induced in mice by a high-fat diet (HFD). The results indicated that GEN significantly reduced HFD-induced body weight and improved lipid homeostasis and glucose tolerance in HFD-fed mice. Furthermore, GEN intervention markedly ameliorated hepatic pathological changes, hepatic dysfunction, and macrophage polarization. Meanwhile, GEN had a beneficial significant impact on colonic pathological changes and the expression of tight junction-related proteins. The results of gut microbiota showed that high-dose GEN intervention was able to down-regulate Firmicutes and Proteobacteria and increase Bacteroidota at the phylum level. At the genus level, GEN intervention increased <i>Lactobacillus</i>, <i>Muribaculum</i>, and <i>Muribaculaceae_unclassified</i> in MASLD mice, and decreased <i>Ruminococcus</i>, <i>Allobaculum</i>, and <i>Helicobacter</i>. In conclusion, GEN attenuated lipid metabolism disorders and hepatic inflammatory reaction <i>via</i> regulating the composition of the gut microbiota and hepatic macrophage polarization in MASLD mice.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Genistein ameliorates non-alcoholic fatty liver disease in mice by modulating gut microbiota and hepatic macrophage polarization

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月18日

查看全文
  • Shanshan Fang,
  • Hui Han,
  • Rui Wang,
  • Siyu Li,
  • Rui Yang,
  • Shomaila Mehmood,
  • Qiang Jia

摘要

Genistein (GEN) exhibits diverse biological activities. This study is conducted to explore the effect of GEN on metabolic dysfunction-associated steatotic liver disease (MASLD) mice. MASLD was induced in mice by a high-fat diet (HFD). The results indicated that GEN significantly reduced HFD-induced body weight and improved lipid homeostasis and glucose tolerance in HFD-fed mice. Furthermore, GEN intervention markedly ameliorated hepatic pathological changes, hepatic dysfunction, and macrophage polarization. Meanwhile, GEN had a beneficial significant impact on colonic pathological changes and the expression of tight junction-related proteins. The results of gut microbiota showed that high-dose GEN intervention was able to down-regulate Firmicutes and Proteobacteria and increase Bacteroidota at the phylum level. At the genus level, GEN intervention increased Lactobacillus, Muribaculum, and Muribaculaceae_unclassified in MASLD mice, and decreased Ruminococcus, Allobaculum, and Helicobacter. In conclusion, GEN attenuated lipid metabolism disorders and hepatic inflammatory reaction via regulating the composition of the gut microbiota and hepatic macrophage polarization in MASLD mice.