<p>Internet of Things (IoT) is an emerging technology that consists of tiny sensors embedded with IoT devices used in e-Health, smart cities and assisted living. IoT devices are equipped with constrained power, memory, and computing capabilities, which creates new security challenges. By integrating sensors and wireless technologies, this cutting-edge technology automates numerous routine tasks in different domains. The main goal of advancing IoT in the existing healthcare system is to automate the monitoring of hospitals and patients’ health by spreading goodwill toward the IoT vision. IoT has gained popularity on practically all platforms that are available. This paper presents a remote patient health monitoring and diagnosis system that uses Message Queuing Telemetry Transport protocol (MQTT) and Internet of Things (IoT) devices with one time pad cryptography. The proposed plan offers end-to-end data secrecy for an IoT system using MQTT that enables e-health and mobility. Patients’ movements inside nursing homes and healthcare facilities are also managed safely without the need for periodic reconfigurations. Prior to communicating through the MQTT protocol, this secure crypto scheme encrypts the message on both the publisher and subscriber ends. According to the results, the proposed scheme is more efficient than delegation-based architecture in terms of security and lightweight communication. The proposed system established communication between patients and medical experts using IoT technologies to alleviate the hospital strain caused by congestion in medical treatment and enable an expressway of medical responses. According to our results the proposed scheme has low computational overhead compared to other solutions that use conventional encryption to guarantee robust protection against most of the IoT security attacks.</p>