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<p>Percutaneous endoscopic gastrostomy (PEG) placement is used for maintaining nutritional status. We aimed to compare overall survival, body weight, and albumin changes between PEG and non-PEG groups. This retrospective cohort study was conducted at Songklanagarind Hospital, Southern Thailand, which included patients (aged ≥ 18 years) with head and neck cancer (HNC) diagnosed between 2007 and 2022. We used the nearest neighbor search to conduct the propensity score matching (PSM) in a 1:1 ratio. Of the 5024 eligible patients, 1604 (31.9%) underwent PEG. After PSM for age, sex, body mass index, type of HNC, time of diagnosis, stage, hemoglobin, albumin and total lymphocyte count, the final PEG and non-PEG groups each included 1,361 patients. The most common cancer type was stage 4 nasopharyngeal cancer. Patients with PEG showed a median survival time of 2.33 (95% confidence interval [CI] 2.15–2.65) years, which was significantly longer than that in the non-PEG group (1.04 [95% CI 0.97–1.10] years; <i>p</i> &lt; 0.0001). The PSM results were similar, whereby patients with PEG showed a greater median survival time of 2.10 (95% CI 1.87–2.32) years compared to those without PEG (1.11 [95% CI 1.03–1.21] years; <i>p</i> &lt; 0.0001). Patients who underwent PEG also showed significant reductions in the loss of body weight and albumin. Multivariable analysis demonstrated that PEG placement was a significant factor for improved 3-month survival (adjusted hazard ratio: 0.24, 95% CI 0.17–0.34). In patients with HNCs, PEG placement improved survival and resulted in a reduced loss of weight and albumin.</p>

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Percutaneous endoscopic gastrostomy improves survival and nutritional outcomes in patients with head and neck cancer

  • 期刊论文

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  • 发表日期：

    2025年11月21日

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  • Suraphon Assawasuwannakit,
  • Chanya Kaittisaksophon,
  • Jirawan Jayuphan,
  • Tanawat Pattarapuntakul,
  • Pimsiri Sripongpun,
  • Chaitong Churuangsuk,
  • Naichaya Chamroonkul,
  • Apichat Kaewdech

摘要

Percutaneous endoscopic gastrostomy (PEG) placement is used for maintaining nutritional status. We aimed to compare overall survival, body weight, and albumin changes between PEG and non-PEG groups. This retrospective cohort study was conducted at Songklanagarind Hospital, Southern Thailand, which included patients (aged ≥ 18 years) with head and neck cancer (HNC) diagnosed between 2007 and 2022. We used the nearest neighbor search to conduct the propensity score matching (PSM) in a 1:1 ratio. Of the 5024 eligible patients, 1604 (31.9%) underwent PEG. After PSM for age, sex, body mass index, type of HNC, time of diagnosis, stage, hemoglobin, albumin and total lymphocyte count, the final PEG and non-PEG groups each included 1,361 patients. The most common cancer type was stage 4 nasopharyngeal cancer. Patients with PEG showed a median survival time of 2.33 (95% confidence interval [CI] 2.15–2.65) years, which was significantly longer than that in the non-PEG group (1.04 [95% CI 0.97–1.10] years; p < 0.0001). The PSM results were similar, whereby patients with PEG showed a greater median survival time of 2.10 (95% CI 1.87–2.32) years compared to those without PEG (1.11 [95% CI 1.03–1.21] years; p < 0.0001). Patients who underwent PEG also showed significant reductions in the loss of body weight and albumin. Multivariable analysis demonstrated that PEG placement was a significant factor for improved 3-month survival (adjusted hazard ratio: 0.24, 95% CI 0.17–0.34). In patients with HNCs, PEG placement improved survival and resulted in a reduced loss of weight and albumin.