Scholarlink

<p>Thyroid cancer is one of the most common endocrine malignancies worldwide, and its prognosis is shaped by both tumor characteristics and social factors such as marital status. This study examined the association between single marital status and disease-specific survival (DSS) in differentiated thyroid cancer (DTC), with particular attention to its interaction with age. We analyzed 153,299 DTC cases diagnosed between 2000 and 2021 from the SEER database. Compared to married patients, single individuals were younger and exhibited larger tumors and more advanced N and M stages, though with more favorable overall TNM stages. Unadjusted Cox regression suggested a protective effect of single status (HR 0.79, 95% CI 0.72–0.87), which reversed after multivariable adjustment (HR 1.32, 95% CI 1.19–1.46). This pattern was consistent in papillary and follicular subtypes but not in Hürthle cell carcinoma. Age modified this effect: single status was protective in patients &lt; 55&#xa0;years (HR 0.89, 95% CI 0.81–0.99) but detrimental in those ≥ 55&#xa0;years (HR 1.12, 95% CI 1.01–1.29). Significant interactions were observed on both multiplicative and additive scales. Fine–Gray competing risk models confirmed these findings. Overall, single status exerts an age-dependent influence on DTC prognosis and warrants consideration in risk assessment.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Single status shows age dependent bidirectional effects in differentiated thyroid cancer

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月18日

查看全文
  • Xiangyi Xiao,
  • Ruixin Zhou,
  • Xiaolin Dou,
  • Hui Ouyang,
  • Xinying Li,
  • Fada Xia,
  • Xiwu Ouyang,
  • Sirui Li,
  • Chen Li

摘要

Thyroid cancer is one of the most common endocrine malignancies worldwide, and its prognosis is shaped by both tumor characteristics and social factors such as marital status. This study examined the association between single marital status and disease-specific survival (DSS) in differentiated thyroid cancer (DTC), with particular attention to its interaction with age. We analyzed 153,299 DTC cases diagnosed between 2000 and 2021 from the SEER database. Compared to married patients, single individuals were younger and exhibited larger tumors and more advanced N and M stages, though with more favorable overall TNM stages. Unadjusted Cox regression suggested a protective effect of single status (HR 0.79, 95% CI 0.72–0.87), which reversed after multivariable adjustment (HR 1.32, 95% CI 1.19–1.46). This pattern was consistent in papillary and follicular subtypes but not in Hürthle cell carcinoma. Age modified this effect: single status was protective in patients < 55 years (HR 0.89, 95% CI 0.81–0.99) but detrimental in those ≥ 55 years (HR 1.12, 95% CI 1.01–1.29). Significant interactions were observed on both multiplicative and additive scales. Fine–Gray competing risk models confirmed these findings. Overall, single status exerts an age-dependent influence on DTC prognosis and warrants consideration in risk assessment.