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<p>Developing novel nanofibrous skin substitutes using biomaterials that exhibit biocompatibility, suitable mechanical strength, and inherent antibacterial activity is essential. In this study, we fabricated polyvinyl alcohol/tragacanth gum/polyaniline (PVA/TG/PANI) nanofibrous membranes via co-electrospinning of PVA/TG and PVA/PANI. The membranes were characterized using scanning electron microscopy, contact angle measurements, swelling tests, and mechanical examination. The co-electrospun nanofibers achieved an average fiber diameter of 176.45 ± 29&#xa0;nm. Contact angle measurements confirmed the hydrophilicity of these membranes, which also exhibited favorable mechanical properties, including sufficient strength and flexibility. Cytocompatibility was assessed by culturing HDF-4 cells; the co-electrospun PVA/TG/PANI membrane demonstrated the highest cell viability at 91.94%, surpassing that of PVA/TG nanofibers. Furthermore, antibacterial activity against <i>E. coli</i> and <i>S. aureus</i> was significantly enhanced in the co-electrospun nanofibers compared to the PVA/TG and PVA/PANI counterparts. Based on these findings, we propose the co-electrospun nanofibrous membrane as a promising scaffold candidate for skin tissue engineering applications.</p>

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Biocompatible and antibacterial co-electrospun tragacanth gum and polyaniline nanofibers for skin tissue engineering

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月4日

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  • Zahra Akbari Kheirabadi,
  • Zahra Nazemi,
  • Mahsa Janmohammadi,
  • Fatemeh Radmanesh,
  • Hamid Reza Moslemi,
  • Mohammad Sadegh Nourbakhsh

摘要

Developing novel nanofibrous skin substitutes using biomaterials that exhibit biocompatibility, suitable mechanical strength, and inherent antibacterial activity is essential. In this study, we fabricated polyvinyl alcohol/tragacanth gum/polyaniline (PVA/TG/PANI) nanofibrous membranes via co-electrospinning of PVA/TG and PVA/PANI. The membranes were characterized using scanning electron microscopy, contact angle measurements, swelling tests, and mechanical examination. The co-electrospun nanofibers achieved an average fiber diameter of 176.45 ± 29 nm. Contact angle measurements confirmed the hydrophilicity of these membranes, which also exhibited favorable mechanical properties, including sufficient strength and flexibility. Cytocompatibility was assessed by culturing HDF-4 cells; the co-electrospun PVA/TG/PANI membrane demonstrated the highest cell viability at 91.94%, surpassing that of PVA/TG nanofibers. Furthermore, antibacterial activity against E. coli and S. aureus was significantly enhanced in the co-electrospun nanofibers compared to the PVA/TG and PVA/PANI counterparts. Based on these findings, we propose the co-electrospun nanofibrous membrane as a promising scaffold candidate for skin tissue engineering applications.