Scholarlink

<p>This study aimed to investigate the relationships among salivary glucose, IL-18, glycemic control, and periodontal status in patients with type 2 diabetes mellitus (T2DM). Seventy-five individuals were categorized according to glycemic status: systemically healthy (controls, <i>n</i> = 25), T2DM with controlled glycemic status (CDM, HbA1C ≤ 7%, <i>n</i> = 21), and T2DM with uncontrolled glycemic status (UCDM, HbA<sub>1C</sub> &gt; 7%, <i>n</i> = 29). Periodontal parameters, including periodontal probing depth (PPD) were recorded. Unstimulated whole saliva samples were analyzed for glucose and IL-18 using enzymatic and ELISA assays, respectively. Pearson correlation and multiple linear regression were used to assess relationships among variables. Salivary glucose and IL-18 levels were significantly elevated in CDM and UCDM groups compared to controls. Salivary glucose levels were associated with glycated hemoglobin (β = 0.429, <i>P</i> &lt; 0.001) and fasting plasma glucose (β = 0.365, <i>P</i> = 0.001) independent of age, sex, PPD, and salivary flow rate. Salivary glucose and IL-18 levels were associated with each other (β = 0.282, <i>P</i> = 0.018) independent of age, sex, PPD, and salivary flow rate. Salivary glucose may serve as a glycemic biomarker, independent of periodontal status. Salivary glucose and IL-18 levels were significantly elevated in patients with T2DM and correlated with each other.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Salivary glucose, salivary interleukin-18, glycemic control, and periodontal status in patients with type 2 diabetes mellitus

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月3日

查看全文
  • Suteera Techatanawat,
  • Pirayaporn Puangmaliwan,
  • Bhornsawan Thanathornwong,
  • Kongthawat Chairatvit,
  • Bishwa Prakash Bhattarai,
  • Weerapan Khovidhunkit,
  • Siribang-on Piboonniyom Khovidhunkit

摘要

This study aimed to investigate the relationships among salivary glucose, IL-18, glycemic control, and periodontal status in patients with type 2 diabetes mellitus (T2DM). Seventy-five individuals were categorized according to glycemic status: systemically healthy (controls, n = 25), T2DM with controlled glycemic status (CDM, HbA1C ≤ 7%, n = 21), and T2DM with uncontrolled glycemic status (UCDM, HbA1C > 7%, n = 29). Periodontal parameters, including periodontal probing depth (PPD) were recorded. Unstimulated whole saliva samples were analyzed for glucose and IL-18 using enzymatic and ELISA assays, respectively. Pearson correlation and multiple linear regression were used to assess relationships among variables. Salivary glucose and IL-18 levels were significantly elevated in CDM and UCDM groups compared to controls. Salivary glucose levels were associated with glycated hemoglobin (β = 0.429, P < 0.001) and fasting plasma glucose (β = 0.365, P = 0.001) independent of age, sex, PPD, and salivary flow rate. Salivary glucose and IL-18 levels were associated with each other (β = 0.282, P = 0.018) independent of age, sex, PPD, and salivary flow rate. Salivary glucose may serve as a glycemic biomarker, independent of periodontal status. Salivary glucose and IL-18 levels were significantly elevated in patients with T2DM and correlated with each other.