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<p>Hepatic fibrosis, resulting from chronic liver injury, can lead to cirrhosis and liver failure. Curcumin shows anti-fibrotic potential but has low bioavailability. This 16-week double-blind, randomized, placebo-controlled trial evaluated the effects of 80&#xa0;mg/day nano-curcumin on liver fibrosis, steatosis, liver function test, and anthropometric parameters in 55 adults (30–70&#xa0;years) with stage ≥ F2 NAFLD-induced fibrosis. Primary outcomes were liver fibrosis and steatosis assessed by FibroScan and FIB-4. Secondary outcomes included changes in liver function tests and anthropometric parameters including body composition. Both groups improved in fibrosis and steatosis, with no significant differences were found between them. The FIB-4 index decreased significantly in the nano-curcumin group (<i>p</i> = 0.022), but between-group differences were not significant (<i>p</i> = 0.135). ALT and AST significantly decreased in the nano-curcumin group (<i>p</i> &lt; 0.001 and <i>p</i> = 0.004), with significant group differences (<i>p</i> &lt; 0.05). GGT reduction was significant between groups after adjustment (<i>p</i> = 0.043), and LDH levels also decreased significantly in the nano-curcumin group (<i>p</i> &lt; 0.001), with a significant between-group difference (<i>p</i> = 0.016). No statistically significant between-group differences were observed in anthropometric parameters. Nano-curcumin improved liver enzymes but showed no significant effect on fibrosis or steatosis compared to placebo. Further research is needed to confirm long-term benefits. <i>Trial registration</i> Iranian Registry of Clinical Trials IRCT20210427051098N2 (Available from: <a href="https://irct.behdasht.gov.ir">https://irct.behdasht.gov.ir</a>).</p>

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Effect of nano-curcumin supplementation on liver fibrosis in patients with NAFLD-associated fibrosis: a double-blind randomized controlled trial

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月30日

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  • Hadis Gerami,
  • Hassan Mozaffari-Khosravi,
  • Asieh Mansour,
  • Amir Ali Sohrabpour,
  • Hossein Poustchi,
  • Amir Pejman Hashemi Taheri,
  • Mahmoud Reza Jaafari,
  • Sara Jambarsang,
  • Sayyed Saeid Khayyatzadeh

摘要

Hepatic fibrosis, resulting from chronic liver injury, can lead to cirrhosis and liver failure. Curcumin shows anti-fibrotic potential but has low bioavailability. This 16-week double-blind, randomized, placebo-controlled trial evaluated the effects of 80 mg/day nano-curcumin on liver fibrosis, steatosis, liver function test, and anthropometric parameters in 55 adults (30–70 years) with stage ≥ F2 NAFLD-induced fibrosis. Primary outcomes were liver fibrosis and steatosis assessed by FibroScan and FIB-4. Secondary outcomes included changes in liver function tests and anthropometric parameters including body composition. Both groups improved in fibrosis and steatosis, with no significant differences were found between them. The FIB-4 index decreased significantly in the nano-curcumin group (p = 0.022), but between-group differences were not significant (p = 0.135). ALT and AST significantly decreased in the nano-curcumin group (p < 0.001 and p = 0.004), with significant group differences (p < 0.05). GGT reduction was significant between groups after adjustment (p = 0.043), and LDH levels also decreased significantly in the nano-curcumin group (p < 0.001), with a significant between-group difference (p = 0.016). No statistically significant between-group differences were observed in anthropometric parameters. Nano-curcumin improved liver enzymes but showed no significant effect on fibrosis or steatosis compared to placebo. Further research is needed to confirm long-term benefits. Trial registration Iranian Registry of Clinical Trials IRCT20210427051098N2 (Available from: https://irct.behdasht.gov.ir).