Scholarlink

<p>Mammalian skin maintains complex repair mechanisms after barrier disruption. Chronic wounds develop when these events are not efficiently completed, increasing infection risk. With ~2% of the population afflicted yearly, chronic wound care needs new technologies. Here, a Phase 0/1 study of one such therapeutic intervention is presented— H<sub>2</sub>O<sub>2</sub> (hydrogen peroxide)-producing electrochemical bandages (e-bandages) controlled by wearable micropotentiostats. The e-bandages generate H<sub>2</sub>O<sub>2</sub> in precise, micromolar concentrations for controlled time intervals. Safety of sterile, 1.77 cm<sup>2</sup> H<sub>2</sub>O<sub>2</sub>-generating e-bandages loaded with 3M hydrogel containing 0.9% sodium chloride was evaluated on healthy adult forearms. Twenty participants were assigned to one of five groups, with groups defined by polarization durations. e-Bandages were worn for 24&#xa0;h and adverse effects evaluated. Most participants experienced no device-related ramifications. Some described discomfort from Tegaderm™, used to secure the devices, and/or hydrogel discoloration. In conclusion, 1.77 cm<sup>2</sup> H<sub>2</sub>O<sub>2</sub>-generating e-bandages were well tolerated on healthy human skin for up to 24&#xa0;h, though further development is needed, supporting future investigation of this therapeutic for chronic wound management. This trial was registered with ClinicalTrials.gov under the identifying number NCT05940207 on 11/07/2023 (first posted date).</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Safety trial assessing 1.77 cm2 H2O2 producing electrochemical bandages on healthy human skin

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年10月30日

查看全文
  • Paige J. Kies,
  • Won-Jun Kim,
  • Derek Fleming,
  • Ibrahim Bozyel,
  • Susan Holtegaard,
  • Shreya Shrivastava,
  • Kaitlin Schwartz,
  • Stephanie Schwieder,
  • Haluk Beyenal,
  • Robin Patel

摘要

Mammalian skin maintains complex repair mechanisms after barrier disruption. Chronic wounds develop when these events are not efficiently completed, increasing infection risk. With ~2% of the population afflicted yearly, chronic wound care needs new technologies. Here, a Phase 0/1 study of one such therapeutic intervention is presented— H2O2 (hydrogen peroxide)-producing electrochemical bandages (e-bandages) controlled by wearable micropotentiostats. The e-bandages generate H2O2 in precise, micromolar concentrations for controlled time intervals. Safety of sterile, 1.77 cm2 H2O2-generating e-bandages loaded with 3M hydrogel containing 0.9% sodium chloride was evaluated on healthy adult forearms. Twenty participants were assigned to one of five groups, with groups defined by polarization durations. e-Bandages were worn for 24 h and adverse effects evaluated. Most participants experienced no device-related ramifications. Some described discomfort from Tegaderm™, used to secure the devices, and/or hydrogel discoloration. In conclusion, 1.77 cm2 H2O2-generating e-bandages were well tolerated on healthy human skin for up to 24 h, though further development is needed, supporting future investigation of this therapeutic for chronic wound management. This trial was registered with ClinicalTrials.gov under the identifying number NCT05940207 on 11/07/2023 (first posted date).