Scholarlink

<p>Cryptogenic stroke, named embolic stroke of undetermined source, refers to patients for whom the etiology of embolism remains unknown. Recently a new cardiac entity, the left-sided septal pouch (LSSP), has been identified as a possible source of thromboembolic events. In the current study, we aimed to perform a systematic review of the literature on this topic and to determine the association between the LSSP presence and occurrence of cryptogenic stroke using meta-analytical methodologies. A detailed search of electronic databases for studies that compared the presence of LSSP in subjects with cryptogenic stroke and non-stroke controls was performed. Data were extracted and pooled into a meta-analysis. We included eight studies in the meta-analysis, in which there were a total of 506 patients with cryptogenic stroke and 1600 patients in the control group. The pooled prevalence of LSSP among cryptogenic stroke patients was 31.6% (95% CI: 20.6–43.8). In the non-stroke control group the pooled prevalence of LSSP was 22.0% (95% CI: 15.0-29.8). The meta-analysis showed that there is a higher risk of cryptogenic stroke in patients with LSSP than in patients without LSSP (OR: 1.57, 95% CI: 1.23–2.01; <i>p</i> &lt; 0.01). A subgroup meta-analysis of transesophageal echocardiography studies demonstrated the same association (OR: 1.59; 95% CI: 1.21–2.08; <i>p</i> &lt; 0.01). In studies where the mean patient age was &lt; 60 years, LSSP was associated with a higher risk of cryptogenic stroke (OR: 1.67; 95% CI: 1.22–2.29; <i>p</i> &lt; 0.01). However, in studies where the mean patient age was &gt; 60 years, the association was not statistically significant (OR: 1.58; 95% CI: 0.75–3.32).</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Association between the left-sided atrial septal pouch and the cryptogenic stroke – an updated systematic review and meta-analysis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年10月27日

查看全文
  • Kamil Tyrak,
  • Jakub Batko,
  • Jakub Hołda,
  • Kacper Jaśkiewicz,
  • Mateusz Hołda

摘要

Cryptogenic stroke, named embolic stroke of undetermined source, refers to patients for whom the etiology of embolism remains unknown. Recently a new cardiac entity, the left-sided septal pouch (LSSP), has been identified as a possible source of thromboembolic events. In the current study, we aimed to perform a systematic review of the literature on this topic and to determine the association between the LSSP presence and occurrence of cryptogenic stroke using meta-analytical methodologies. A detailed search of electronic databases for studies that compared the presence of LSSP in subjects with cryptogenic stroke and non-stroke controls was performed. Data were extracted and pooled into a meta-analysis. We included eight studies in the meta-analysis, in which there were a total of 506 patients with cryptogenic stroke and 1600 patients in the control group. The pooled prevalence of LSSP among cryptogenic stroke patients was 31.6% (95% CI: 20.6–43.8). In the non-stroke control group the pooled prevalence of LSSP was 22.0% (95% CI: 15.0-29.8). The meta-analysis showed that there is a higher risk of cryptogenic stroke in patients with LSSP than in patients without LSSP (OR: 1.57, 95% CI: 1.23–2.01; p < 0.01). A subgroup meta-analysis of transesophageal echocardiography studies demonstrated the same association (OR: 1.59; 95% CI: 1.21–2.08; p < 0.01). In studies where the mean patient age was < 60 years, LSSP was associated with a higher risk of cryptogenic stroke (OR: 1.67; 95% CI: 1.22–2.29; p < 0.01). However, in studies where the mean patient age was > 60 years, the association was not statistically significant (OR: 1.58; 95% CI: 0.75–3.32).