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<p><i>Houttuynia cordata</i> essential oil (HCEO) is a promising ingredient for acne-focused phytocosmetics. This in vitro study evaluated its volatile compounds, antimicrobial, antioxidant, wound-healing, anti-melanogenic, and anti-inflammatory properties, along with the stability of topical oil‑in‑water emulsions. GC-MS analysis identified <i>n-</i>decanoic acid (46.21%), β-myrcene (14.082%), and 2-undecanone (11.01%) as the main components. HCEO inhibited the growth of <i>Staphylococcus aureus</i>, <i>Candida albicans</i>, <i>Staphylococcus epidermidis</i>, and <i>Cutibacterium acnes</i>. It displayed antioxidant activity, with IC<sub>50</sub> values of 13.25 ± 0.09&#xa0;mg/mL (DPPH) and 17.44 ± 0.16&#xa0;mg TEAC/g (FRAP). No cytotoxicity was observed in NIH/3T3 fibroblasts and RAW 264.7 macrophages (up to 500&#xa0;µg/mL). HCEO enhanced fibroblast migration by 26.94% ± 1.12% at 400&#xa0;µg/mL. It inhibited melanin synthesis in B16F10 and A375 cells, with IC<sub>50</sub> values of 200.61 ± 2.19 and 152.16 ± 1.97&#xa0;µg/mL, respectively, and tyrosinase activity (IC<sub>50</sub> of 48.00 ± 0.01&#xa0;µg/mL). Additionally, HCEO suppressed nitric oxide production in LPS-stimulated macrophages (IC<sub>50</sub> of 1.176 ± 0.084&#xa0;µg/mL). Oil-in-water emulsions containing HCEO maintained physical stability for eight weeks, indicating suitability for cosmetic product development. These findings suggest HCEO has potential as a natural ingredient for advanced skincare formulations targeting acne and skin inflammation, although further work is needed to optimise loading, assess skin permeation, and confirm efficacy in vivo.</p>

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In vitro bioactivities and formulation stability of Houttuynia cordata essential oil for cosmetic applications

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月24日

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  • Sarita Sangthong,
  • Phanuphong Chaiwut,
  • Punyawatt Pintathong,
  • Benjarat Suwannawong,
  • Montra Srisayam,
  • Tinnakorn Theansungnoen,
  • Kasemsiri Chandarajoti,
  • Hesamoddin Arabnozari,
  • Satyajit D. Sarker,
  • Lutfun Nahar

摘要

Houttuynia cordata essential oil (HCEO) is a promising ingredient for acne-focused phytocosmetics. This in vitro study evaluated its volatile compounds, antimicrobial, antioxidant, wound-healing, anti-melanogenic, and anti-inflammatory properties, along with the stability of topical oil‑in‑water emulsions. GC-MS analysis identified n-decanoic acid (46.21%), β-myrcene (14.082%), and 2-undecanone (11.01%) as the main components. HCEO inhibited the growth of Staphylococcus aureus, Candida albicans, Staphylococcus epidermidis, and Cutibacterium acnes. It displayed antioxidant activity, with IC50 values of 13.25 ± 0.09 mg/mL (DPPH) and 17.44 ± 0.16 mg TEAC/g (FRAP). No cytotoxicity was observed in NIH/3T3 fibroblasts and RAW 264.7 macrophages (up to 500 µg/mL). HCEO enhanced fibroblast migration by 26.94% ± 1.12% at 400 µg/mL. It inhibited melanin synthesis in B16F10 and A375 cells, with IC50 values of 200.61 ± 2.19 and 152.16 ± 1.97 µg/mL, respectively, and tyrosinase activity (IC50 of 48.00 ± 0.01 µg/mL). Additionally, HCEO suppressed nitric oxide production in LPS-stimulated macrophages (IC50 of 1.176 ± 0.084 µg/mL). Oil-in-water emulsions containing HCEO maintained physical stability for eight weeks, indicating suitability for cosmetic product development. These findings suggest HCEO has potential as a natural ingredient for advanced skincare formulations targeting acne and skin inflammation, although further work is needed to optimise loading, assess skin permeation, and confirm efficacy in vivo.