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<p>Anaplastic thyroid cancer (ATC) and papillary thyroid carcinoma (PTC) exhibit significant differences in clinical behavior and immune microenvironments, particularly concerning the mechanisms underlying CD8<sup>+</sup> T cell dysfunction. However, these specific mechanisms have yet to be thorThe original blots and abbreviations are presented in Supplemeoughly investigated. The present study utilized single-cell RNA sequencing (scRNA-seq) data to conduct a comprehensive analysis of CD8<sup>+</sup> T cells in the thyroid tissues of patients diagnosed with ATC and PTC. The results of the study indicate that CD8<sup>+</sup> T cells in ATC display disruptions in energy supply and marked signs of exhaustion. Conversely, CD8<sup>+</sup> T cells in PTC are more prone to maintaining a stable expression of immunosuppression-related membrane proteins through posttranslational modifications. This study highlights the distinct mechanisms of CD8<sup>+</sup> T cell exhaustion in two types of thyroid cancer, offering valuable insights into the regulation of their immune microenvironments.</p>

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Single-cell transcriptome analysis reveals the potential heterogeneous mechanism of CD8+ T cell immune dysfunction in thyroid cancer

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月14日

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  • Qinling Zhang,
  • Kaiyu Song,
  • Chaolin Li,
  • Xicheng Song,
  • Jin Zhou

摘要

Anaplastic thyroid cancer (ATC) and papillary thyroid carcinoma (PTC) exhibit significant differences in clinical behavior and immune microenvironments, particularly concerning the mechanisms underlying CD8+ T cell dysfunction. However, these specific mechanisms have yet to be thorThe original blots and abbreviations are presented in Supplemeoughly investigated. The present study utilized single-cell RNA sequencing (scRNA-seq) data to conduct a comprehensive analysis of CD8+ T cells in the thyroid tissues of patients diagnosed with ATC and PTC. The results of the study indicate that CD8+ T cells in ATC display disruptions in energy supply and marked signs of exhaustion. Conversely, CD8+ T cells in PTC are more prone to maintaining a stable expression of immunosuppression-related membrane proteins through posttranslational modifications. This study highlights the distinct mechanisms of CD8+ T cell exhaustion in two types of thyroid cancer, offering valuable insights into the regulation of their immune microenvironments.