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<p>The BREAst screening Tailored for HEr (BREATHE) study was established to pilot a personalised, risk-based breast cancer screening programme for a multi-ethnic Asian population. Between October 2021 and December 2023, 4592 women aged 35–59 were enrolled (73% response rate). Follow-up from February 2022 to June 2024 included 4112 participants (8.6% loss to follow-up). Data collected encompassed demographics, lifestyle factors, reproductive risks, breast cancer awareness, screening behaviours, programme satisfaction, mammography outcomes (density and recall status), and genotype data. Above-average breast cancer risk increased with age: 2% in women aged 35–39, 31% in 40–49, and 42% in 50–59. Findings suggests that women valued the knowledge of their breast cancer risk and were motivated to attend mammography. The BREATHE study confirms the feasibility and acceptability of a personalised risk-based screening programme in a multi-ethnic Asian population, highlighting the value of tailored protocols to improve early detection and outcomes. Further details are available in the study protocol and online at <a href="https://blog.nus.edu.sg/breathe/">https://blog.nus.edu.sg/breathe/</a>.</p>

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Profile of the BREATHE cohort for risk-based breast screening in Singapore

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月10日

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  • Peh Joo Ho,
  • Jenny Liu,
  • Su-Ann Goh,
  • Alexis Jiaying Khng,
  • Nur Khaliesah Mohamed Riza,
  • Ying Jia Chew,
  • Desmond Luan Seng Ong,
  • Yi Wang,
  • Fook Ming Hew,
  • Pooja Jagmohan,
  • Premilla Gopinathan Pillay,
  • Yonggeng Goh,
  • Han Yang Ong,
  • Abrar Mohammed Alsunbul,
  • Han Boon Oh,
  • Christopher Hang Liang Keh,
  • Chi Hui Chin,
  • Sing Cheer Kwek,
  • Zhi Peng Zhang,
  • Swee Tian Quek,
  • Sujith Wijerathne,
  • Jingmei Li,
  • Philip Choong Tsau Iau,
  • Mikael Hartman

摘要

The BREAst screening Tailored for HEr (BREATHE) study was established to pilot a personalised, risk-based breast cancer screening programme for a multi-ethnic Asian population. Between October 2021 and December 2023, 4592 women aged 35–59 were enrolled (73% response rate). Follow-up from February 2022 to June 2024 included 4112 participants (8.6% loss to follow-up). Data collected encompassed demographics, lifestyle factors, reproductive risks, breast cancer awareness, screening behaviours, programme satisfaction, mammography outcomes (density and recall status), and genotype data. Above-average breast cancer risk increased with age: 2% in women aged 35–39, 31% in 40–49, and 42% in 50–59. Findings suggests that women valued the knowledge of their breast cancer risk and were motivated to attend mammography. The BREATHE study confirms the feasibility and acceptability of a personalised risk-based screening programme in a multi-ethnic Asian population, highlighting the value of tailored protocols to improve early detection and outcomes. Further details are available in the study protocol and online at https://blog.nus.edu.sg/breathe/.